In fibrous-bed bioreactor, the cells are immobilized on the fibers in the bioreactor.
Following is scanning electron microscope photos of human
osteosarcoma cells in an artificial growth medium, a fibrous-bed bioreactor.
The cells cling to Dacron fibers. Osteosarcoma is the most common malignant
bone tumor. These cells have been genetically-engineered to produce a protein
called Del-1. Photos courtesy of the Department of Chemical Engineering,
Ohio State University.
Del1a -- Osteosarcoma cells, magnification 100X.
Del1b -- Osteosarcoma cells, magnification 950X.
Del1c -- Osteosarcoma cells, magnification 500X.
Del1d -- Osteosarcoma cells, magnification 2000X.
Schematic of Hollow Fiber Bioreactor and a Single Hollow Fiber in a Bioreactor.
An example of using fibrous bed bioreactor in continuous fermentation:
Acid Production from Fructose by Clostridium formicoaceticum Immobilized
in a Fibrous-Bed Bioreactor
Last modify: 05/01/2000, by Xuezhen Kang