© 2000-2008 Ingenuity Systems, Inc. All rights reserved. Pathway -log(p-value) Ratio Molecules Hepatic Fibrosis / Hepatic Stellate Cell Activation 2.69E00 4.58E-02 MYL9,MYL6,CCL2,IFNGR2,TGFB3,EDNRA Chemokine Signaling 2.04E00 5.33E-02 CCL2,PPP1R12B,PRKCA,PRKCB1 VDR/RXR Activation 1.98E00 5E-02 SERPINB1,KLF4,PRKCA,PRKCB1 Leukocyte Extravasation Signaling 1.94E00 3.19E-02 ITGB2,TIMP3,MYL6,VIL2,PRKCA,PRKCB1 FXR/RXR Activation 1.77E00 4.17E-02 BAAT,MLXIPL,CYP19A1,PPARGC1A Glucocorticoid Receptor Signaling 1.38E00 2.26E-02 CD3G,YWHAH,CCL2,ANXA1,TGFB3,NR3C1 Xenobiotic Metabolism Signaling 1.34E00 2.4E-02 PPP2CB,GSTM5,ALDH18A1,PPARGC1A,PRKCA,PRKCB1 Actin Cytoskeleton Signaling 1.32E00 2.25E-02 MYLK,MYL9,MYL6,VIL2,PPP1R12B,GSN Estrogen Receptor Signaling 1.01E00 2.54E-02 PHB2,NR3C1,PPARGC1A Natural Killer Cell Signaling 9.66E-01 2.73E-02 NCK1 (includes EG:4690),PRKCA,PRKCB1 PPARα/RXRα Activation 9.62E-01 2.27E-02 TGFB3,PPARGC1A,PRKCA,PRKCB1 Urea Cycle and Metabolism of Amino Groups 9.41E-01 2.5E-02 ALDH18A1,ODC1 Glutamate Metabolism 9.02E-01 2.56E-02 GNPNAT1,GPT Aminosugars Metabolism 8.42E-01 1.9E-02 GNPNAT1,UAP1 Integrin Signaling 8.08E-01 2.08E-02 MYLK,ITGB2,ITGAV,PPP1R12B Lysine Biosynthesis 7.91E-01 1.56E-02 AADAT Axonal Guidance Signaling 7.66E-01 1.55E-02 MYL9,MYL6,NCK1 (includes EG:4690),ABLIM1,PRKCA,PRKCB1 Fatty Acid Biosynthesis 7.24E-01 2.04E-02 MCCC2 Synaptic Long Term Depression 7.15E-01 1.84E-02 PPP2CB,PRKCA,PRKCB1 PDGF Signaling 7.11E-01 2.7E-02 PRKCA,PRKCB1 Aryl Hydrocarbon Receptor Signaling 7.03E-01 1.97E-02 GSTM5,TGFB3,ALDH18A1 Lysine Degradation 6.94E-01 1.39E-02 AADAT,PLOD3 ERK/MAPK Signaling 6.83E-01 1.77E-02 PPP2CB,YWHAH,PRKCA,PRKCB1 Taurine and Hypotaurine Metabolism 6.67E-01 2.13E-02 BAAT Wnt/β-catenin Signaling 6.5E-01 1.82E-02 PPP2CB,DKK3,TGFB3 O-Glycan Biosynthesis 6.34E-01 2.33E-02 GALNT10 One Carbon Pool by Folate 6.18E-01 2.63E-02 GART VEGF Signaling 6.08E-01 2.17E-02 PRKCA,PRKCB1 Neuregulin Signaling 6.01E-01 2.2E-02 PRKCA,PRKCB1 Interferon Signaling 5.76E-01 3.45E-02 IFNGR2 Antigen Presentation Pathway 5.63E-01 2.56E-02 HLA-DPB1 NRF2-mediated Oxidative Stress Response 5.44E-01 1.67E-02 GSTM5,PRKCA,PRKCB1 T Cell Receptor Signaling 5.41E-01 1.96E-02 SHB,CD3G Nucleotide Excision Repair Pathway 5.38E-01 2.86E-02 XPA Fc Epsilon RI Signaling 5.29E-01 2E-02 PRKCA,PRKCB1 Complement System 5.16E-01 2.78E-02 C7 Synaptic Long Term Potentiation 4.74E-01 1.8E-02 PRKCA,PRKCB1 G-Protein Coupled Receptor Signaling 4.58E-01 1.51E-02 EDNRA,PRKCA,PRKCB1 EGF Signaling 3.93E-01 2.13E-02 PRKCA Pentose Phosphate Pathway 3.93E-01 1.12E-02 TKT Huntington's Disease Signaling 3.89E-01 1.29E-02 CASP1,PRKCA,PRKCB1 Apoptosis Signaling 3.83E-01 1.47E-02 SPTAN1,PRKCA Metabolism of Xenobiotics by Cytochrome P450 3.67E-01 9.39E-03 GSTM5,CYP19A1 Alanine and Aspartate Metabolism 3.54E-01 1.15E-02 GPT Hepatic Cholestasis 3.49E-01 1.23E-02 PRKCA,PRKCB1 NF-κB Signaling 3.49E-01 1.4E-02 RELB,PRKCB1 B Cell Receptor Signaling 3.38E-01 1.35E-02 EGR1,PRKCB1 Cell Cycle: G1/S Checkpoint Regulation 3.31E-01 1.67E-02 TGFB3 GM-CSF Signaling 3.15E-01 1.61E-02 PRKCB1 Sphingolipid Metabolism 3E-01 1.09E-02 SGMS1 Hypoxia Signaling in the Cardiovascular System 3E-01 1.41E-02 UBE2J1 Arachidonic Acid Metabolism 2.97E-01 9.48E-03 PTGIS,CYP19A1 IL-4 Signaling 2.91E-01 1.47E-02 NR3C1 Tryptophan Metabolism 2.82E-01 8.44E-03 AADAT,CYP19A1 PI3K/AKT Signaling 2.79E-01 1.14E-02 PPP2CB,YWHAH LXR/RXR Activation 2.73E-01 1.23E-02 CCL2 Glutathione Metabolism 2.65E-01 9.62E-03 GSTM5 Eicosanoid Signaling 2.61E-01 1.19E-02 PTGIS Bile Acid Biosynthesis 2.53E-01 1.04E-02 BAAT Pyruvate Metabolism 2.49E-01 6.9E-03 ACOT12 Calcium Signaling 2.48E-01 9.8E-03 MYL9,MYL6 TGF-β Signaling 2.42E-01 1.2E-02 TGFB3 FGF Signaling 2.25E-01 1.19E-02 PRKCA PTEN Signaling 2.18E-01 1.09E-02 YWHAH PPAR Signaling 2.18E-01 1.05E-02 PPARGC1A Dopamine Receptor Signaling 2.15E-01 1.1E-02 PPP2CB IL-6 Signaling 2.15E-01 1.1E-02 CYP19A1 IGF-1 Signaling 2.12E-01 1.09E-02 YWHAH Linoleic Acid Metabolism 1.98E-01 8.13E-03 CYP19A1 p38 MAPK Signaling 1.98E-01 1.05E-02 TGFB3 Glycerolipid Metabolism 1.98E-01 6.9E-03 DGAT1