© 2000-2008 Ingenuity Systems, Inc. All rights reserved. Function -log(p-value) Molecules Cancer 4.65E-10-1.45E-02 LGALS3,ATXN1,IFI16,TGFBR3,PRSS2 (includes EG:5645),RNF103,ODC1,MYLK,EZH2,LUM,ITGAV,CCT5,JUP,PTGIS,ATF3,PTP4A3,PHB2,GSN,KLF4,GART,SEL1L,MYL9,CD3G,IGF2,TGFB3,ST14,VSNL1,SERPINB1,GSTM5,PVRL3,CLU,NR3C1,SGMS1,CCL2,DKK3,CYP19A1,ANXA1,STEAP2,CASP1,GATA6,MEG3,CREB3L1,PRKCA,TIMP3,EGR1,RELB,VIM,KCNH2,XPA,ITGB2,RPL5,EDNRA,PRKCB1 Cellular Movement 4.65E-10-1.45E-02 LGALS3,CAPZA2,CLU,NCK1 (includes EG:4690),ODC1,MYLK,CCL2,CYP19A1,DKK3,EZH2,ANXA1,VIL2,ABHD2,CASP1,ITGAV,C7,JUP,PRKCA,TIMP3,ATF3,EGR1,PTP4A3,VIM,KCNH2,GSN,KLF4,SEL1L,ITGB2,IGF2,TGFB3,CALD1,ST14,VSNL1,PRKCB1 Cellular Growth and Proliferation 6.04E-07-1.45E-02 LGALS3,TGFBR3,IFI16,PRSS2 (includes EG:5645),NCK1 (includes EG:4690),ODC1,GNPNAT1,EZH2,VIL2,LUM,ITGAV,CCT5,JUP,ATF3,PTP4A3,GSN,KLF4,SEL1L,MYL9,CD3G,IGF2,TGFB3,CGRRF1,CLU,FIP1L1,NR3C1,SGMS1,CCL2,CYP19A1,DKK3,ANXA1,STEAP2,CASP1,GATA6,MEG3,CAV2,HLA-DPB1,PRKCA,TIMP3,OPTN,EGR1,RELB,VIM,XPA,ITGB2,SHB,EIF4A1,EDNRA,PRKCB1 Reproductive System Disease 1.26E-05-1.45E-02 TIMP3,SERPINB1,LGALS3,GSTM5,IFI16,EGR1,CLU,NR3C1,ODC1,SEL1L,MYL9,IGF2,DKK3,CYP19A1,EZH2,STEAP2,CASP1,ITGAV,GATA6,EDNRA,JUP,ST14,PRKCB1,PRKCA Cell-To-Cell Signaling and Interaction 2.63E-05-1.35E-02 LGALS3,IFI16,PVRL3,PRSS2 (includes EG:5645),CLU,MYLK,OGT,GNPNAT1,CCL2,DKK3,ANXA1,ITGAV,CNTN3,JUP,PRKCA,TIMP3,PTP4A3,EGR1,PHB2,GSN,ITGB2,IGF2,TGFB3,VSNL1,PRKCB1 Respiratory System Development and Function 6.91E-05-1.1E-02 CYP19A1,TGFB3,GATA6,CAV2,HLA-DPB1,NR3C1 Tissue Morphology 6.91E-05-1.1E-02 PTGIS,ATF3,LGALS3,TKT,RELB,VIM,GSN,KCNH2,NR3C1,ODC1,MYLK,SLMAP,MYL9,CCL2,CYP19A1,TGFB3,PPP1R12B,GATA6,CALD1,DGAT1,PLOD3,PPARGC1A,PRKCA Dermatological Diseases and Conditions 8.97E-05-1.45E-02 RELB,EGR1,PHB2,IFNGR2,CLU,GSN,NR3C1,ODC1,XPA,SHB,ITGB2,CYP19A1,CASP1,ITGAV,DGAT1,PRKCB1 Immunological Disease 8.97E-05-1.35E-02 LGALS3,RELB,EGR1,CLU,IFNGR2,GSN,NR3C1,XPA,ITGB2,CCL2,ANXA1,VIL2,CASP1,PCBP2,PRKCA,PRKCB1 Inflammatory Disease 8.97E-05-1.23E-02 TIMP3,LGALS3,EEF2,EGR1,RELB,IFNGR2,PHB2,CLU,GPT,VIM,FIP1L1,NR3C1,ODC1,XPA,ITGB2,CD3G,CCL2,CYP19A1,LUM,CASP1,CALD1,CREB3L1,PRKCB1,PRKCA Endocrine System Development and Function 1.03E-04-1.1E-02 IGF2,CYP19A1,EGR1,ANXA1,CLU,NR3C1 Organ Morphology 1.03E-04-1.1E-02 IGF2,CYP19A1,ANXA1,RELB,EGR1,DGAT1,CAV2,NR3C1 Cell Death 1.18E-04-1.35E-02 LGALS3,GSTM5,ATXN1,IFI16,BAT3,TGFBR3,CLU,NCK1 (includes EG:4690),NR3C1,SGMS1,ODC1,MYLK,GNPNAT1,DKK3,CYP19A1,PPP1R2,VIL2,ANXA1,ITGAV,CASP1,C7,GATA6,JUP,PCBP2,CREB3L1,GALNT10,PRKCA,PTGIS,TIMP3,ATF3,OPTN,EGR1,PRUNE2,TNKS2,GSN,KLF4,XPA,ITGB2,CD3G,IGF2,TGFB3,PPARGC1A,PRKCB1 Carbohydrate Metabolism 1.19E-04-1.45E-02 OGT,GNPNAT1,UAP1 Hair and Skin Development and Function 1.19E-04-1.1E-02 TIMP3,RELB,CLU,NR3C1,KLF4,ODC1,OGT,ITGB2,ITGAV,JUP,DGAT1,PRKCA,PRKCB1 Nucleic Acid Metabolism 1.19E-04-2.41E-03 GNPNAT1,UAP1 Small Molecule Biochemistry 1.19E-04-1.17E-02 PTGIS,BAAT,SLC26A6,GSN,NR3C1,ODC1,LASS4,MYLK,ITGB2,OGT,IGF2,GNPNAT1,CCL2,ANXA1,ITGAV,C7,EDNRA,NUCB2,UAP1,PLOD3,PPARGC1A,PRKCA,PRKCB1,MCCC2 Hematological Disease 1.8E-04-1.35E-02 EGR1,CLU,GSN,NR3C1,XPA,ITGB2,ANXA1,VIL2,ITGAV,CASP1,EDNRA,PCBP2,PRKCB1,PRKCA Endocrine System Disorders 2.04E-04-1.1E-02 TIMP3,LGALS3,ATF3,EEF2,CLU,NR3C1,KLF4,ITGB2,IGF2,CYP19A1,ANXA1,EDNRA,PPARGC1A,PRKCB1,PRKCA Gastrointestinal Disease 2.63E-04-1.22E-02 TIMP3,ATF3,CLU,RNF103,GSN,NR3C1,KLF4,XPA,CD3G,IGF2,ANXA1,ITGAV,CASP1,GATA6,PRKCB1,PRKCA Metabolic Disease 3.53E-04-1.1E-02 TIMP3,LGALS3,ATF3,EEF2,CLU,GSN,KLF4,NR3C1,ITGB2,IGF2,CYP19A1,ANXA1,EDNRA,DGAT1,PEX12,PPARGC1A,PRKCB1,PRKCA Cell Cycle 3.55E-04-1.29E-02 ATF3,LGALS3,EGR1,IFI16,CLU,VIM,KLF4,NR3C1,XPA,SEL1L,IGF2,RPL5,PPP1R2,EZH2,ITGAV,GATA6,PRKCA,PRKCB1 Embryonic Development 3.55E-04-1.45E-02 TIMP3,ITGB2,IGF2,TGFB3,ITGAV,GSN,ODC1 Hematological System Development and Function 3.55E-04-1.35E-02 TIMP3,LGALS3,EGR1,IFI16,RELB,IFNGR2,GSN,NR3C1,MYLK,ITGB2,IGF2,CCL2,CYP19A1,ANXA1,CASP1,ITGAV,C7,PRKCB1,PRKCA Immune Response 3.55E-04-1.41E-02 TIMP3,LGALS3,EGR1,GSN,NR3C1,MYLK,ITGB2,CCL2,CYP19A1,ANXA1,ITGAV,C7,CASP1,PRKCA,PRKCB1 Immune and Lymphatic System Development and Function 3.55E-04-1.41E-02 ITGB2,IGF2,CCL2,RELB,IFI16,EGR1,ANXA1,IFNGR2,ITGAV,C7,NR3C1 Cellular Function and Maintenance 4.02E-04-1.1E-02 IFI16,EGR1,CLU,NCK1 (includes EG:4690),GSN,NR3C1,ST5,ITGB2,IGF2,CCL2,CYP19A1,ANXA1,TGFB3,ITGAV,GATA6,NUCB2,PRKCA,PRKCB1,PPARGC1A Organismal Injury and Abnormalities 4.2E-04-1.3E-02 PTGIS,TIMP3,ATF3,LGALS3,RELB,EGR1,CLU,NR3C1,ITGB2,CCL2,CYP19A1,ITGAV,CASP1,EDNRA,HLA-DPB1,PLOD3,PRKCA,PPARGC1A,PRKCB1 Cell Signaling 6.64E-04-1.1E-02 CCL2,ITGAV,NUCB2,PRKCB1,PRKCA Vitamin and Mineral Metabolism 6.64E-04-1.1E-02 CCL2,ITGAV,NUCB2,PRKCB1,PRKCA Cardiovascular System Development and Function 7.51E-04-1.35E-02 LGALS3,TKT,PTP4A3,TGFBR3,VIM,ITGB2,IGF2,CCL2,CYP19A1,ANXA1,ITGAV,TGFB3,GATA6,PRKCA Connective Tissue Disorders 1.17E-03-1.1E-02 TIMP3,ATF3,EEF2,PHB2,CLU,FIP1L1,VIM,NCK1 (includes EG:4690),NR3C1,XPA,ITGB2,IGF2,GNPNAT1,CCL2,CYP19A1,LUM,CASP1,CALD1,PRKCB1,PRKCA Infectious Disease 1.17E-03-1.1E-02 CCL2,RELB,CLU,IFNGR2,ITGAV,CASP1,CALD1,KCNH2,NR3C1 Skeletal and Muscular Disorders 1.17E-03-1.39E-02 EEF2,CLU,IFNGR2,PHB2,VIM,FIP1L1,SGCB,KCNH2,NR3C1,XPA,ITGB2,IGF2,CCL2,CYP19A1,LUM,CALD1,PPARGC1A,PRKCA,PRKCB1 Connective Tissue Development and Function 1.71E-03-1.14E-02 LGALS3,ATF3,TKT,NCK1 (includes EG:4690),GSN,ITGB2,IGF2,CCL2,CYP19A1,VIL2,ITGAV,TGFB3,DGAT1 Cellular Assembly and Organization 1.74E-03-1.29E-02 LGALS3,OPTN,HPS1,NCK1 (includes EG:4690),RAB34,GSN,NR3C1,KLF4,MYLK,ITGB2,TGFB3,CALD1,CAV2,PEX12,PPARGC1A Cellular Compromise 1.74E-03-1.1E-02 MYLK,VIL2,TGFB3,NR3C1,XPA Gene Expression 1.74E-03-1.15E-02 ATF3,EGR1,IFI16,TGFBR3,NR3C1,KLF4,IGF2,CYP19A1,TGFB3,CASP1,MEG3,PPARGC1A,PRKCA Neurological Disease 1.74E-03-1.29E-02 PTGIS,EGR1,TKT,ATXN1,CLU,NR3C1,XPA,ITGB2,CCL2,ITGAV,EDNRA,CREB3L1,PRKCB1 Tissue Development 1.84E-03-1.41E-02 TIMP3,IFI16,EGR1,PTP4A3,PVRL3,PRSS2 (includes EG:5645),CLU,GSN,NR3C1,OGT,ITGB2,GNPNAT1,IGF2,CCL2,DKK3,ANXA1,ITGAV,C7,JUP,CNTN3,VSNL1,PRKCA Lipid Metabolism 1.94E-03-1.1E-02 PTGIS,IGF2,ANXA1,EDNRA,GSN,NR3C1,PPARGC1A,LASS4,PRKCB1 Skeletal and Muscular System Development and Function 3.11E-03-1.45E-02 IFI16,GSN,KCNH2,MYLK,SLMAP,MYL9,ITGB2,IGF2,CCL2,EZH2,ITGAV,PPP1R12B,CALD1,MBNL1,PPARGC1A,PRKCA Reproductive System Development and Function 3.19E-03-1.1E-02 IGF2,CYP19A1,CLU,NR3C1,PRKCB1,PRKCA Cellular Development 3.21E-03-1.45E-02 LGALS3,IFI16,CLU,NCK1 (includes EG:4690),NR3C1,ODC1,CCL2,CYP19A1,VIL2,EZH2,ANXA1,ITGAV,GATA6,ZNF488,PRKCA,ATF3,RELB,EGR1,HPS1,IFNGR2,GSN,KLF4,XPA,ITGB2,CD3G,IGF2,TGFB3,EDNRA,MBNL1,PRKCB1,PPARGC1A Amino Acid Metabolism 3.81E-03-1.17E-02 BAAT,MYLK,ITGB2,PLOD3,PRKCB1,PRKCA,MCCC2 Post-Translational Modification 3.81E-03-1.17E-02 BAAT,MYLK,ITGB2,PLOD3,PRKCB1,PRKCA Cell Morphology 4.08E-03-1.1E-02 TIMP3,LGALS3,ATF3,EGR1,GSN,KCNH2,KLF4,ODC1,MYLK,ITGB2,ST5,CCL2,DKK3,VIL2,ANXA1,PRKCA Respiratory Disease 4.37E-03-1.3E-02 LGALS3,RELB,EGR1,CASP1,ITGAV,NR3C1 Tumor Morphology 4.7E-03-1.1E-02 CCL2,CYP19A1,CLU,ITGAV,JUP,KCNH2,PRKCA Molecular Transport 4.79E-03-1.1E-02 ITGB2,CCL2,SLC26A6,ANXA1,GSN,NR3C1,ODC1,PRKCB1,LASS4 Cardiovascular Disease 5.06E-03-1.1E-02 PTGIS,RELB,EGR1,CLU,SGCB,KCNH2,NR3C1,KLF4,SHB,IGF2,CCL2,EDNRA,DGAT1,PPARGC1A,PRKCA Organismal Development 5.92E-03-1.1E-02 ITGB2,IGF2,CYP19A1,TNKS2,DGAT1,NR3C1,KLF4 Hepatic System Disease 6.14E-03-1.1E-02 IGF2,GPT,PRKCA Renal and Urological Disease 6.14E-03-1.12E-02 IGF2,LGALS3,ATF3,CCL2,CYP19A1,IFI16,TGFBR3,AMMECR1,CLU,EDNRA,NR3C1 Renal and Urological System Development and Function 7.04E-03-1.1E-02 TIMP3,ITGB2,TKT,ITGAV Nutritional Disease 7.22E-03-7.22E-03 IGF2,CYP19A1,NR3C1,PPARGC1A Hepatic System Development and Function 9.94E-03-1.1E-02 LGALS3,EGR1,ITGAV Behavior 1.1E-02-1.1E-02 CYP19A1 DNA Replication, Recombination, and Repair 1.1E-02-1.1E-02 VIM,NR3C1,XPA Developmental Disorder 1.1E-02-1.1E-02 PTGIS,CYP19A1,EDNRA Digestive System Development and Function 1.1E-02-1.1E-02 IGF2,PRKCA Genetic Disorder 1.1E-02-1.14E-02 PTGIS,ITGB2,ATXN1,TKT,CLU,KCNH2,ODC1,PRKCB1 Nervous System Development and Function 1.1E-02-1.1E-02 TKT,EGR1,NR3C1 Ophthalmic Disease 1.1E-02-1.1E-02 CLU,NR3C1 Organ Development 1.1E-02-1.1E-02 IGF2,KLF4,NR3C1 Organismal Functions 1.1E-02-1.1E-02 ITGB2 Viral Function 1.1E-02-1.1E-02 ST13,NR3C1