DUANE F. BRULEY

• B.S., Chemical Engineering, University of Wisconsin, 1956
  
• ORSORT, Nuclear Engineering, Oak Ridge School of Reactor Technology, 1957
  
• M.S., Mechanical Engineering, Stanford University, 1959
  
• Ph.D., Chemical Engineering, University of Tennessee, 1962
  

Description of Research: Whitaker Foundation Special Opportunity Award

• "Symbiosis of Biomedical and Bioprocess Engineering Utilizing TQM to enhance Health Care Quality and Delivery". This special project involves education and research in the manufacturing and utilization of Protein C in a total quality management (TQM) environment.
  
  
• Tissue Engineering. Utilizing the discovery of rDNA technology to enhance protein synthesis and delivery in tissue. Specific interest is in the functioning of liver to produce Protein C and the transport processes throughout the body.
  
  
• Bioseparation/Affinity Chromatography. Research focuses on the identification of system parameters and the scale-up of systems using phenomenological modeling. Affinity chromatography separation of high molecular weight proteins is being studied to maximize productivity. Heterogeneous equilibrium between ligand and product molecules is under investigation.
  
  
• Drug Delivery. Experimental and theoretical studies concerning the administration of high molecular weight therapeutic proteins, in particular, Protein C. Biodegradable matrices and inhalation methods.
  
  
• Pharmaco-kinetics. Projects focused on the understanding of the production and utilization of high molecular weight therapeutic proteins in vivo and the influence of anti-coagulants and anti-thrombotics on the relative levels of these proteins in the tissues of the body.
  
  
• Biosensors. Use of the fundamentals of chemistry, physics, and biology to quantify the protein levels in human tissues and biosystems.
  
  
• Process Dynamics and Control. The study of the temporal behavior of biological systems to apply the principles of automatic control for the optimization of process functioning.
  
  
• Mathematical Modeling and Computer Simulation of Transport Phenomena. Theoretical and empirical approaches to obtain mathematical formulations of biological systems for computer simulation.
  

Publications:

• BOOK: PROTEIN C AND RELATED ANTICOAGULANTS, Editors, D.F. Bruley and W. Drohan, Gulf Publishing Company, 1990.
  
• BOOK: OXYGEN TRANSPORT TO TISSUE - XV; Editors, P. Vaupel, R. Zander, and D.F. Bruley, Advances in Experimental Medicine and Biology, Plenum Press, 1994.
  
• Bruley, D.F. and J.W. Prados, ÒThe Frequency Response Analysis of a Wetted Wall Adiabatic Humidifier,Ó AIChE Journal, 11, 612, September, 1964.
  
• Bruley, D.F. and M.H. Knisely, ÒA Simulation of Oxygen Transport in Blood Capillaries Carrying Pure Plasma", Proc. Seventh International Conference on Medical and Biological Engineering, Stockholm, Sweden, p. 440, August 1967.
  
• Kang, K. A., Afuwape, S. A. and Bruley, D. F., "A Computer Simulation of Oxygen Partial Pressure and Temperature Profiles during Hyperthermia", p. 183 - 192, Advances in Experimental Medicine and Biology, 317, Erdman, G., and Bruley, D.F., (eds.), Plenum Press, New York, 1992.
  
• Bruley, D.F., ÒModeling Oxygen Transport: Development of Methods and Current State Symposium in Honor of Professor Dr. Gehard ThewsÓ, Oxygen Transport to Tissue XV, Advances in Experimental Medicine and Biology, 345, 807-814, Plenum Press, New York, 1994.
  
• Kang, K.A., Bruley, D.F., Londono, J.M., and Chance, B., "Highly Scattering Optical System Identification via Frequency Response Analysis of Optical HIR-TRS Spectra", Annals of Biomedical Engineering, 22, 241-253, 1994.
  

Duane F. Bruley