PUBLICATIONS

Ph.D. Dissertation: “Optical method for measurements of chemical concentrations”, Bulgarian Academy of Sciences, November 1993.

Books

1.    Neykov, A., Kostov, Y. A Practical Guide for Biotechnology Measurements. Technical University, Sofia, Bulgaria, 1999 (textbook, in bulgarian).

 

Book Chapters

2.    Sai Satish, R., Venkatesh S., Kostov, Y (2013) Solution Deposited Plasmonic Nanofilms and their applications. In: Handbook of functional nanomaterials, Volume I – Synthesis and Modification, Ed. M. Aliofkhazraei, Nova Science Publishers New York, NY, pp. 333-349

3.    Rasooly, A., Kostov, Y., Bruck, H.(2012) Charged-couple Device (CCD) Detectors for Lab-on-a Chip (LOC) Optical Analysis. Microfluidic Diagnostics: Methods in Molecular Biology, Vol. 949 Jenkins, Gareth; Mansfield, Colin D. (Eds.) (Book Series). Humana Press

4.    Lam H., Kostov Y. (2010) Optical instrumentation for bioprocess monitoring. Advances in biochemical engineering/biotechnology 116 (Book Series) Springer, pp.1-28

5.    Kostov, Y. (2008) Photodiode-based measurement system for biosensors. In: Biosensors and Biodetection. Methods in Molecular Biology 503 (Book Series). Springer Protocols. pp.307-323

6.     Kostov, Y. Sergeev N., Wilson S., Herold K.E., Rasooly A. (2008) A simple portable electroluminescence-based CCD detector. In: Biosensors and Biodetection. Methods in Molecular Biology 503 (Book Series). Springer Protocols. pp.259-272

7.    L. Tolosa, Y. Kostov, and G. Rao. Fluorescence-Based Sensors for Bioprocess Monitoring. In: Fluorescence Sensors and Biosensors, Ed. R. Thompson, CRC Press, Boca Raton, FL (2005).

8.    Y.Kostov (2005) Sensors for Bioprocess Monitoring, In: Bioprocess Systems – Modelling, control and optimization, ed. S.M. Tzonkov, Sofia, Bulgaria (in Bulgarian).

 

Patents

9.    Kostov Y. et al (2012) Remote non-invasive parameter sensing system and method. European patent PCT/US2010052286

10.              Kostov Y. et al. (2008) Ratiometric fluorescent pH sensor for non-invasive monitoring. US Patent 7,390,462/ June 24, 2008

11.              Kostov Y. et al. (2006) Device for discrimination of fluorescence lifetimes and uses therefore. US patent 7,041,986/ May 9, 2006

12.              Kostov Y. et al. (2006) Ion-Sensitive Fluorescence Optical Sensor. US patent 7,029,630/ April 18, 2006

13.              Kostov, Y. et al. (2003) Ratiometric fluorometer. US Patent 6,563,585/May 13, 2003

14.              Kostov, Y. (1993) Optical Transducer For Chemical Sensors. BG Patent 95881/February 10, 1993

 

Peer-reviewed Journal Articles

15.              Chatterjee, M., Ge, X., Kostov, Y., Tolosa, L., Rao, G. (2014) A rate-based transcutaneous CO2 sensor for respiration monitoring. Physiological Measurement, (submitted)

16.              Chatterjee, M., Ge, X., Uplekar, S.,Kostov, Y., Croucher, L., Rao, G. (2014) A Unique Noninvasive Approach to Monitoring Dissolved O2 and CO2 in Cell Culture. Biotechnology & Bioengineering 112,  104-110.

17.              Kim, E.J., Fleischman, A.J., Kostov, Y., Muschler, G.F., Roy, S. (2014) Growth Characteristics of Human Bone Marrow Derived Osteoprogenitor Cells on Surface Microtextured Substrates. J. Biomaterials and Tissue Eng. 4, 107-117

18.              Chatterjee, M., Ge, X., Kostov, Y., L., Rao, G. (2014) Safe and rapid monitoring of transcutaneous gases using a novel non-equilibrium approach. Journal of Medical devices, 2012, 6(1): 017566-1.

19.              Tran, K., Gibson, A., Wong,D., Tilahun, D., Good, T., Ram, G., Woo, D., Tolosa, L., Tolosa, M., Kostov, Y., Rao, G., Selock, N., Frizzell, M., Fulda V. (2014) Designing a Low-Cost Multifunctional Incubator for Neonates. J Lab Autom 19, 332-337

20.              Chatterjee, M., Ge, X., Kostov, Y., Tolosa, L., Rao, G. (2014) A novel approach towards noninvasive monitoring of transcutaneous CO2. Medical Engineering & Physics, 2014, 36(1):136-9.

21.              Ge,X., Kostov, Y., Henderson, R., Selock, N., Rao, G. (2014) A low-cost fluorescent sensor for pCO2 measurements. Chemosensors 2, 108-120.

22.              Ge, X., Rao, G., Kostov, Y., Kanjananimmanont, S., Viscardi, R. M., Woo, H., Tolosa, L. (2013) Detection of Trace Glucose on the Surface of a Semipermeable Membrane Using a Fluorescently Labeled Glucose-Binding Protein: A Promising Approach to Noninvasive Glucose Monitoring. J. Diabetes Sci Technol 7, 4-12

23.              Chattergee, K., Lam, H., Rao, G., Robucci, R., Kostov, Y. (2013) Low-Cost Fluorescence-Based Temperature Sensing for Neonatal Care. IEEE Sensors 2013, DOI:10.1109/ICSENS.2013.6688180

24.              Kuester, T., Lam, H., Robucci, R., Rao, G., Kostov, Y. (2013) High resolution fluorescence–based temperature sensor for stand-off detection in physiological range. IEEE Sensors 2013, 4pp.,  DOI: 10.1109/ICSENS.2013.6688138

25.              Kostov, Y., Ge, X., Rao, G., Tolosa, L. (2014) Portable system for the detection of micromolar concentrations of glucose. Measurement Science and Technology 25, 025701-9pp

26.              Gurramkonda, C., Mupparapu, K., Abouzeid, R., Kostov, Y., Rao, G (2013) Fluorescence-Based Method and a Device for Rapid Detection of Microbial Contamination. PDA J. Pharm. Sci. and Tech. 68, 164-171, doi: 10.5731/pdajpst.2014.00951

27.              Ge, X.,  Kostov, Y., Tolosa, L., Rao, G. (2012) Study on low-cost calibration-free pH sensing with disposable optical sensors. Anal. Chim. Acta 734, 79-87

28.              Balsam,J., Bruck, H.A., Kostov, Y., Rasooly,A(2012) Image stacking approach to increase sensitivity of fluorescence detection using a low cost complementary metal-oxide-semiconductor (CMOS) webcam. Sensors and Actuators B 171–172,141–147.

29.              Dingkai Guo, Xing Chen, Shilpa Vadala, Jennie Leach, Yordan Kostov, William W. Bewley, Chul-Soo Kim, Mijin Kim, Chadwick L. Canedy, Charles D. Merritt, Igor Vurgaftman, Jerry R. Meyer and Fow-Sen Choa (2012) Neuron absorption study and mid-IR optical excitations", Proc. SPIE 8207, 82075;

30.              Lam H.T., Kostov Y., Tolosa L., Falk S., Rao G. (2012) A high-resolution non-contact fluorescence-based temperature sensor for neonatal care. Meas. Sci. Technol. 23 035104 (7pp)

31.              Balsam, J., Ossandon, M., Kostov, Y., Bruck, H.A., Rasooly, A (2011) Lensless CCD-based fluorometer using a micromachined optical Söller collimator. Lab Chip 11, 941-949

32.              Bambrick L.L., Kostov Y., Rao G. (2012) In vitro cell culture pO2 is significantly different from incubator pO2. Biotechnology Progress 27, 1185–1189

33.              Kwon, S., Kostov, Y., Rasooly, A., Rao, G., Ghosh, U. (2011) Study of the biouptake of single walled carbon nanotubes using a fluorescence based method. Environmental Chemistry Letters 9, 235-241

34.              Chen, X.,Cheng, L., Guo, D. Kostov, Y., Choa, F-S. (2011) Quantum cascade laser based standoff photoacoustic chemical detection. Optics Express 19,  20251-20257

35.              Yang M, Sun S, Kostov Y, Rasooly A. (2011) An automated point-of-care system for immunodetection of staphylococcal enterotoxin B. Anal. Biochem. 416, 74–81

36.              Rao G, Kostov Y, Moreira A, Frey D, Hanson M, Jornitz M, Reif O-V, Baumfalk R, Qualitz J. (2010) Non-invasive sensors as enablers of “smart” disposables. BioProcess International 7, Supplement 1, pp24-27

37.              Sai Sathish R, Kostov Y, Rao G. (2010) Low-Cost Plastic Plasmonic Substrates for Operation in Aqueous Environments. Appl. Spectroscopy 64,1234-1237

38.              Sai Sathish R, Kostov Y, Rao G. (2010) Studies of surface adsorbed fluorescently labeled Casein and Concanavalin A using surface plasmon coupled emission. Plasmonics 5, 383-387.

39.              Sun S, Yang M, Kostov Y, Rasooly A.(2010) ELISA-LOC: lab-on-a-chip for enzyme-linked immunodetection. Lab Chip. 10, 2093-2100. DOI: 10.1039/c005141a.

40.              Sun S, Francis J, Sapsford KE, Kostov Y, Rasooly A. (2010) Multi-wavelength Spatial LED illumination based detector for in vitro detection of Botulinum Neurotoxin A Activity. Sens Actuators B Chem. 146, 297-306.

41.              Yang M, Sun S, Bruck HA, Kostov Y, Rasooly A. (2010) Electrical percolation-based biosensor for real-time direct detection of staphylococcal enterotoxin B (SEB). Biosens Bioelectron. 25, 2573-8

42.              Yang M, Bruck HA, Kostov Y, Rasooly A. (2010) Biological semiconductor based on electrical percolation. Anal Chem. 82 ,3567-72.

43.              Yang M, Sun S, Kostov Y, Rasooly A. (2010) Lab-On-a-Chip for carbon nanotubes based immunoassay detection of Staphylococcal Enterotoxin B (SEB). Lab Chip. 10, 1011-7.

44.              Smith, D., Sai Sathish. R, Kostov, Y., Rao, G. (2010) Solution Deposition of Nanometer Scale Silver Films as an Alternative to Vapor Deposition for Plasmonic Excitation, Thin Solid Films, 518 3772–3777

45.              Sai Sathish, R., Y. Kostov, Y., Rao, G. (2010) Surface plasmon-coupled emission from Rhodamine- 6G aggregates for ratiometric detection of ethanol vapors. IFBME proceedings 32, 309-312.

46.              Lam, H., Kostov, Y., Rao G, Tolosa L. (2010) A luminescence lifetime assisted ratiometric fluorimeter for biological applications Rev Sci Instr. 80, 124302; doi:10.1063/1.3264106

47.              Sai Sathish. R, Kostov, Y., Rao, G. (2009) Spectral resolution of molecular ensembles under ambient conditions using surface plasmon coupled fluorescence emission. Appl. Optics. 48, 5348-53.

48.              Sun, S., Ossandon, M., Kostov Y., Rasooly A. (2009) Lab-on-a-chip for botulinum neurotoxin a (BoNT-A) activity analysis. Lab-on-a-chip 9 3275-81

49.              Sathish RS, Kostov Y, Rao, G. (2009) High-resolution surface plasmon coupled resonant filter for monitoring of fluorescence emission from molecular multiplexes. Appl. Phys.Let. 94, 223113

50.              Lam H, Kostov Y, Rao G., Tolosa L. (2009) Low-cost optical lifetime assisted ratiometric glutamine sensor based on glutamine binding protein. Anal Biochem. 383, 61-67

51.              Acosta M., Ymele-Leki, P.,  Kostov Y., Leach J. (2009) Fluorescent Microparticles for sensing cell microenvironment oxygen levels within 3D scaffolds. Biomaterials 30, 3068-74

52.              Sapsford KE, Francis J, Sun S, Kostov Y, Rasooly A. (2009) Miniaturized 96-Well ELISA Chips for Staphylococcal Enterotoxin B Detection Using Portable Colorimetric Detector. Anal. Bioanal Chem. 394, 499-505

53.              Sai Sathish. R, Kostov, Y., Smith, D., Rao, G (2009) Solution-deposited thin silver films on plastic surfaces for low-cost applications in plasmon-coupled emission sensors. Plasmonics 4,127–133

54.              Vuppu, S., Kostov, Y., Rao, G. (2008) Low-cost wireless optical ratiometric pH sensor Meas. Sci.&Technol. 20, 045202 (7pp)

55.              Badugu, R., Kostov, Y., Rao, G., Tolosa, L. (2008) Development and Application of an Excitation Ratiometric Optical pH Sensor for Bioprocess Monitoring. Biotechnol. Prog. 24, 1393-1401

56.              Lam, H., Kostov, Y., Rao, G., Tolosa, L. (2008) Low-Cost Optical Lifetime Assisted Ratiometric Glutamine Sensor Based on Glutamine Binding Protein. Analytical Biochemistry 383, 61-67.

57.              Yang, M., Kostov, Y., Bruck, H., Rasooly, A. (2008) Carbon Nanotubes with Enhanced Chemiluminescence (CNT-ECL) Immunoassay for CCD-based Detection of Staphylococcal Enterotoxin B (SEB) in Food. Anal. Chem. 80, 8532–8537

58.              Sapsford,K.E., Sun, S., Francis, J. Sharma, S., Kostov, Y., Rasooly, A.(2008) A fluorescence detection platform using spatial electroluminescent excitation for measuring botulinum neurotoxin A activity Biosensors and Bioelectronics 24, 618-625

59.              Yang, M., Kostov, Y., Rasooly, A.(2008) Carbon nanotubes based optical immunodetection of Staphylococcal Enterotoxin B (SEB) in food. Int. J.Food Microbiology 127, 78-83

60.              Aliasgar A., Kostov, Y., Rao, G. (2008) Optical pH probe replacement. IEEE Sensors 9, 219-220

61.              Acosta M., Kostov Y., Leach J. (2007) Microfluidic bioreactors as tools for monitoring cell microenvironment. Revista Cientifica Colegio de Quimicos de Puerto Rico 01-07 14-15

62.              Kim, E.J., Boehm, C.A., Fleischman, A.J., Muschler, G.F., Kostov, Y.K., Roy, S. (2008) Modulating human connective tissue progenitor (CTP) cell behavior on cellulose acetate (CA) scaffolds by surface microtextures. Journal of Biomedical Materials Research: Part A 90, 1198-205.

63.              Smith, D.S., Kostov, Y., Govind Rao, G. (2008) Signal enhancement of surface plasmon-coupled directional emission via a conical mirror. Appl.Sspectroscopy 47, 5229-5234

64.              Chandrasekharan, N., Ibrahim, S., Kostov, Y., Rao, G. (2008) Ratiometric Alcohol Sensor based on a Polymeric Nile Blue. Bioautomation 9, 31-39

65.              Szmacinski, H., Smith, D. S., Hanson, M.A., Kostov, Y., Lakowicz, J.R., Rao, G. (2007) A novel method for monitoring monoclonal antibody production during cell culture, Biotechnol. Bioeng.100, 448-457

66.              Hanson, M.A., Ge, X., Kostov, Y., Brorson, K.A., Moreira, A.R., Rao, G. (2007) Comparisons of optical pH and Dissolved Oxygen sensors with traditional electrochemical probes during mammalian cell culture. Biotechnol.Bioeng. 97, 833-841

67.              Smith, D., Kostov, Y., Rao, G. (2007) SPCE-Based Sensors. 1. Oxygen Sensing Using Surface-Plasmon Coupled Emission from Ruthenium Probes. Sensors and Actuators B 127,  432–440

68.              Petrova S., Kostov Y., Jeffris K., Rao G. (2007) Optical Ratiometric sensor for alcohol measurements. Anal. Letters 40, 715-727

69.              Vallejos, J.R., Kostov, Y., Ram, A., French, J., Marten, M.R. , Rao, G. (2006) Optical Analysis of Liquid Mixing in a Minibioreactor. Biotechnol.Bioeng. 93, 906-911

70.              Harms, P., Kostov, Y., Ram, A., French, J.A., Rao, G. (2006) Design of a 24 Station Microbioreactor Platform Biotechnol. Bioeng. 93, 6-13.

71.              Dalal, N.G., Cha, H.J. Kramer, S.F., Kostov, Y., Rao, G., Bentley, W.E. (2006) Rapid non-invasive monitoring of baculovirus infection for insect larvae using green fluorescent protein reporter under early-to-late promoter and a GFP-specific optical probe. Process Biochemistry 41, 947-950 .

72.              Ge X., Hanson M., Shen H., Kostov Y, Brorson KA, Frey DD, Moreira AR, Rao G. (2006)Validation of an optical sensor-based high-throughput bioreactor system for mammalian cell culture. J. Biotechnology 122, 293-306.

73.              Kostov, Y.; Smith, D. S.; Tolosa, L.; Rao, G.; Gryczynski, I.; Gryczynski, Z.; Malicka, J.; Lakowicz, J. R.; (2005). Directional Surface Plasmon-Coupled Emission from a 3 nm Green Fluorescent Protein Monolayer. Biotechnol. Progress 21, 1731-1735.

74.              Smith, D., Kostov, Y., Rao, G., Gryczynski, I., Malicka, J., Gryczynski, Z., Lakowicz, J.R. (2005) First Observation of Surface Plasmon-Coupled Emission due to LED Excitation. J. Fluorescence 15, 895-900.

75.              Vallejos, J.R., Kostov, Y., Marten, M.R. , Rao, G. (2005) Confocal Optical System: A Novel Noninvasive Sensor To Study Mixing. Biotechnol. Progress 21, 1531-1536.

76.              Ge, X., Kostov, Y., Rao, G. (2004) Low-Cost Noninvasive Optical CO2 Sensing System for Fermentation and Cell culture, Biotechnol.Bioeng. 89, 329-334

77.              Entcheva, E., Bien, H., Yin, L., Chung, C.-Y., Farrell, M., Kostov, Y. (2004) Functional Cardiac Cell Constructs on Cellulose-Based Scaffolding, Biomaterials 25, 5753-5762.

78.              Sin, A., Chin, K.C., Jamil, M.F., Kostov, Y., Rao, G., Shuler, M.L. (2004) The Design and Fabrication of Three Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors, Biotechnol. Prog. 20, 338-345.

79.              Kostov, Y., Rao, G. (2003) Low-cost gated system for monitoring phosphorescence lifetimes. Rev. Sci. Instr. 74, 4129-4133.

80.              Kermis, H.R., Kostov, Y., Rao, G. (2003) Rapid method for the preparation of a robust optical pH sensor. Analyst 128, 1181-1186.

81.              Entcheva E, Kostov Y, Tchernev E, and Tung L. (2003) All-solid-state system for fluorescence imaging of transmembrane potentials and [Ca2+]i in cardiac cells. IEEE Transactions on Biomedical Imaging 52, 333-341.

82.              Ge, X., Kostov, Y., Rao, G. (2003) High-stability non-invasive autoclavable naked optical CO2 sensor, Biosensors& Bioelectronics 18, 857-865.

83.              Kramer, S. F., Kostov, Y., Rao, G., Bentley, W.E. (2003) Ex vivo monitoring of protein production in baculovirus-infected Trichoplusia ni larvae with a GFP-specific optical probe. Biotechnology and Bioengineering 83, 241-247.

84.              Kostov, Y., Rao, G. (2003) Ratio measurements in oxygen determinations: wavelength ratiometry, lifetime discrimination and polarization detection. Sens. Actuators B 90, 139-142.

85.              Tolosa, L., Kostov, Y., Harms, P., Rao, G. (2002) Noninvasive measurement of dissolved oxygen in shake flasks. Biotechnology and Bioengineering 80, 594-597.

86.              Kermis, H.R., Kostov, Y., Harms, P., Rao, G. (2002) A dual-excitation ratiometric fluorescent sensor for non-invasive bioprocess monitoring: development and application. Biotechnol. Prog. 18, 1047-1053

87.              Kang, Y.S., Kostov, Y. (2002) Ratiometric pH measurement using LysoSensor DND-192. J.Biochem Mol. Biol. 35, 384-388.

88.              Harms, P., Kostov, Y., Rao, G. (2002) Bioprocess monitoring. Curr. Opinion Biotechnol. 13, 124-127

89.              Kostov, Y., Gryczynski, Z., Rao, G. (2002) Polarization oxygen sensor: a template for a new class of fluorescence-based sensors. Anal. Chem. 74, 2167-2171.

90.              Kostov, Y., Harms, P., Rao, G. (2001) Ratiometric sensing using dual-frequency lifetime discrimination. Anal. Biochem. 297, 105-108.

91.              Kostov Y., Harms P., Randers-Eichhorn L., Rao G. (2001) Low-cost microbioreactor for high-throughput bioprocessing. Biotechnology and Bioengineering, 72, 346-352.

92.              Kostov Y., Rao G. (2000) Low-cost optical instrumentation for biomedical measurements. Rev. Sci. Instr., 70, 4361-4374.

93.              Kostov Y., Albano C.R., Rao, G. (2000) All-solid-state GFP sensor. Biotechnology and Bioengineering 70, 473-477.

94.              Kostov Y., Van Houten, K.A., Harms, P., Pilato, R.S., Rao, G. (2000) A unique oxygen analyzer combining dual emission probe and low-cost ratiometric fluorimeter. Applied Spectroscopy 54, 864-868.

95.              Kostov Y., Harms P., Pilato R.S, Rao G. (2000) Ratiometric oxygen sensing: detection of dual-emission ratio through a single emission filter. The Analyst, 125, 1175-1178.

96.              Kostov Y., Neykov A.(2000) Rapid method for preparation of pH sensitive membranes. Anal. letters, 33 (3), 413 – 423.

97.              Kostov Y., Rao. G. (1999) Simple low-cost device for fluorescence ratiometric measurements. Rev. Sci. Instr., 70, 4466-4470.

98.              Kostov, Y., Comte, A., Scheper, T. (1998) All-Solid State Phase-Shift Oxygen Sensor for Biotechnology. Biotechnology &  Bioengineering Quarterly. 12(4), 201-205.

99.              Kostov, Y. (1996) Optical Methods And Sensors Using Immobilized Reagents For Chemical Concentrations Measurements. Automatics and Informatics, 30, 45-48.

100.          Kostov, Y. (1994) Model of an Optical Wide-range pH Sensor for Drinking Water. Automatics and Informatics, 28, 84-87

101.          Kostov, Y., Yotova, L., Tzonkov, S., Krysteva, M. (1993) Membranes For Optical pH Sensors. Anal. Chim. Acta, 280, 15-19.

102.          Kostov, Y., Yotova, L., Tzonkov, S. (1993) Dynamical Model Of Optical Absorption-Based pH Sensor. Analyst, 118, 987-990

103.          Tzonkov,S., Kostov,Y., Neykov,A. (1992) Transfer Function Of Optical Absorbtion-Based pH Sensor And Its Linearization. Bioautomation 12,  44-51

104.          Kostov,Y. (1991) Immobilized Bromophenol Blue As Sensing Element In pH Sensor, Sensors and Actuators B, 8, 99-101

 

Peer Reviewed Proceedings Articles

105.          Tolosa, L., Xudong Ge, X., Kostov, Y., Lakowicz, J.R., Rao, G. (2003) Dual-Emitting Biosensors for Glucose and Glutamine from Genetically Engineered E. coli Binding Proteins. Proceedings SPIE, v. 4967 , 19-25

106.          Kostov, Y., Tolosa, L., O’Connell, K., Anderson, P., Liu, Y., van Beek, N., Rao, G. (2003) Monitoring of DsRed protein concentration in frozen insect larvae. Proceedings SPIE, v. 4967 , 100-107

107.          Neykov, A., Stoyanov, S., Kostov, Y. (1997) Analysis of the nonlinear errors of one-enzyme biosensor system. “Bioprocess Engineering ‘97” (BioPS’97), 14-15 October 1997, Sofia, Bulgaria, IV.7-IV.12.

108.          Kostov, Y. (1997) Optimization of an optical pH-sensitive membranes. “Bioprocess Engineering ‘97” (BioPS’97), 14-15 October 1997, Sofia, Bulgaria, IV.13-IV.16.

109.          Kostov, Y. (1996) Computer-based transducer for absoption-based optical sensors. 7-th National Scienyific Symposium with international participation “METROLOGY & reliability 96“, September 24-27, 1996, Sozopol, 202-205.

110.          Kostov, Y. (1995) Comparative Analysis Of Two Methods For Optical Measurement Of Dissolved Oxygen Concentration. International WorkShop and Young Scientists School BIOPROCESS ENGINEERING 95, Sofia, October 2-5,1995, 82-84.

111.          Neykov, A., Kostov, Y. (1995) Precision Models Of Amperometrical Biosensors In The Linear Region. International WorkShop and Young Scientists School BIOPROCESS ENGINEERING 95, Sofia, October 2-5,1995, 78-81.

112.          Sharkov,I., Kostov, Y. (1995) Optical Sensor For Biomass Concentration. International conference “Automatics and Informatics '95”, Sofia, 7-9 November 1995, 422-424. 

113.          Kostov, Y., Tzonkov, S., Petrov, V. (1994) Applicability Of LEDs In Optical  Chemical Sensors. International WorkShop and Young Scientists School “BIOPROCESS ENGINEERING”, Sofia, September 26-29,1994, 72-74.

114.          Yotova, L., Kostov, Y., S., Krysteva, Ignatova, Z. (1994) Optical Absorption Sensor For Benzilpenizillin. International WorkShop and Young Scientists School BIOPROCESS ENGINEERING, Sofia, September 26-29,1994, 21-24.

115.          Kostov, Y., Tzonkov, S. (1993) Microphotometer For Fixed Wavelength. International conference "Metrology and control in agroecology METROAGROECO '93", Sofia, Bulgaria. 315-319

116.          Kostov,Y. (1991) Optical Sensor For pH. IV National Scientific Session "Automation of Biotechnological Processes and Biomedical Investigations", September 17-19, 1991, Sofia, Bulgaria. 90-94

117.          Gushev, A., Kostov, Y. (1991) Homogenizing device. IV National Scientific session “Automation of Biotechnology processes and Biomedical investigations”, Sofia, Bulgaria, September 17-19, 1991. pp 86-89

 

Peer Reviewed Abstracts

118.          Gowda, H., Kostov, Y., Tolosa, L., Lam. H. (2012) Dual Fluorescent Glutamine Sensor based on Glutamine Binding Protein URCAD 2012, April 25, 2012, UMBC, Baltimore, MD

119.          Kostov Y., Ge X.,  Henderson R., Rao G. (2012) Fluorescence-Based Microfluidic Sensor for Measurements of pCO2 in Seawater. Pittcon 2012, March 11-15, 2012, Orange County Convention Center, Orlando, FL.

120.          Lam, H., Kostov, Y., Rao, G., Falk, S. (2012) Non-Contact Fluorescence Based Temperature Sensor for Neonatal Care. Pittcon 2012, March 11-15, 2012, Orange County Convention Center, Orlando, FL.

121.          Gowda, H., Lam, H., Kostov, Y. (2011) Dual Fluorescent Temperature and Glutamine Sensor Based on Glutamine Binding Protein, Annual Biomedical Research Conference for Minority Students, Baltomore, MD

122.          Bionanocompsites - APL

123.           Sai Sathish,R., Kostov,Y., Smith,D.,Rao, G. (2009) Application of surface plasmon-coupled emission as a low-cost resonant filter to monitor discrete excited states of fluorophores, 238th ACS National Meeting, Washington, DC, August 16-20, 2009

124.          Kostov,Y.,  Minghui Yang,M., Rasooly, A.(2009), High sensitivity carbon nanotubes based assay for detection of Staphylococcal enterotoxin B in food. 238th ACS National Meeting, Washington, DC, August 16-20, 2009

125.          Ge,X., Kostov, Y., Rao, G. (2009) Low-cost high-performance pCO2 sensor for ocean monitoring, 238th ACS National Meeting, Washington, DC, August 16-20, 2009

126.          Kim, E.J., Boehm, C., Fleischman, A., Muschler, G, Kostov, Y., Roy, S. (2007)  Modulating Human Connective Tissue Progenitor (CTP) Cell Behavior On Cellulose Acetate Scaffolds By Surface Microtextures, ASME 2007 Summer Bioengineering Conference, June 20 - 24, 2007, Keystone Resort & Conference Center, Keystone, CO.

127.          Kostov, Y., Ghosh, U., Rao, G. (2007) Sterilizable Optical Sensor for Alcohol Measurements, ACS National Meeting, Boston, MA, August 2007,

128.          Kostov, Y., Rao, G. (2007) Miniature and low-cost wireless sensor platform for environmental monitoring, ACS National Meeting, Boston, MA, August 2007 .

129.          D. Smith, Kostov, Y. and G. Rao, (2007) Ultra-fast Sensing Based on Surface Plasmon-Coupled Directional Emission, ACS National Meeting, Boston, MA, August 2007.

130.          D. Smith, Kostov, Y. and G. Rao, (2006) Promising high-sensitivity fluorescence sensing method: Surface plasmon-coupled emission, ACS National Meeting, San Francisco, CA, September 2006.

131.          D. Smith, Kostov, Y. and G. Rao, (2006)Surface Plasmon-Coupled Directional Emission Based Sensing, Graduate Research Conference, University of Maryland at Baltimore County, April 2006.

132.          Petrova S., Kostov, Y., Rao, G. (2006) Optical Ratiometric Sensor for Alcohol Measurements. 57th Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, 2006, March 12-17, 2006, Orlando, Florida

133.          Kostov, Y., Rao, G. (2005) Bioprocess monitoring in microbioreactors.  SIM Annual Meeting, August 21-25, 2005, Chicago, IL. Invited paper

134.          Rao., G., Kostov, Y., Ge, X., Tolosa, L., Vallejos, J., Hanson, M., Frey, D., Marten, M., Moreira, A. (2005) Culture at the small-scale: challenges, solutions and opportunities. Biochemical Engineering meeting July 2005 - Eng. Foundation.

135.          Kostov, Y., Rao, G. (2004) Measurement and control in microbioreactors: achievements and challenges. Micro-bioprocessing Engineering: Dechema Information day, Frankfurt, Germany, 11 November 2004. Invited Paper.

136.          Kostov, Y., Kermis, H., Rao, G. (2004) On-Line Monitoring Of pH In Shake-Flask Fermentations,  7th European Conference on Optical Chemical Sensors and Biosensors EUROPT(R)ODE VII, Madrid, Spain, April 4-7 2004.

137.          Kostov, Y. Ge, X., Tolosa, L., Rao, G. (2004) In-situ optical sensors: optoelectronics meets biotechnology College-Tag “Optische Sensoren in der Biotechnologie“, March 18, 2004, Göttingen, Germany. Invited paper

138.          Rao, G., Kostov, Y., Tolosa, L., Ge, X., Harms, P., Das, M. (2004) Novel Optical Sensors for High Throughput Culture, Cell Culture Engineering IX, Cancun, Mexico, March 2004.

139.          Bien H, Farrell M, Yu H-J, Kostov Y and Entcheva E. (2003) Lifetime fluorescence measurements of oxygen uptake in cardiac cell networks using oxygen-sensitive scaffolds. Annual BMES Meeting, Nashville TN, October 2003

140.          Entcheva E, Kostov Y, Bien H, Yin L, Chung CY, Dasari V and Farrell M. Versatile cellulose-based scaffolding for growing functional cardiac cell networks. Annual BMES Meeting, Nashville TN, October 2003.

141.          Kostov, Y., Harms, P., Rao G. (2002) On-line optical density measurements in shake flasks. 224th ACS National Meeting, Boston MA, August 2002.

142.          Kostov, Y., Tolosa, L., Rao, G. (2002) Long-lifetime ratiometric pH sensing. 224th ACS National Meeting, Boston MA, August 2002.

143.          Kermis, H. R., Kostov, Y., Harms, P., Rao, G. (2002) Dual-excitation ratiometric fluorescent sensor: Application to noninvasive bioprocess monitoring. 224th ACS National Meeting, Boston MA, August 2002.

144.          Harms, P., Kostov, Y., Kermis, H.R., Rao, G.(2002) Twenty-four simultaneously monitored fermentations in a standard plate format. 224th ACS National Meeting, Boston MA, August 2002.

145.          Kostov Y., Harms P., Rao G. (2002) Luminescence-based oxygen sensing in high-fluorescence background environment. IMCS 9: 9th International meeting on chemical sensors, Boston, MA, July 7-10 2002.

146.          Kostov, Y,, Gryczynski, Z., Rao, G. (2002) Polarization oxygen sensor: a template for a new class Fluorescence based sensors. BECON 2002: Sensors for biological research and medicine. NIH, Bethesda, Maryland, June 24-25, 2002, p.41.

147.          Tolosa L., Ge X., Kermis H., Kostov Y., Rao G. (2002) Ratiometric optical sensing using proteins from E. Coli permease system as Biosensors. BECON 2002: Sensors for biological research and medicine. NIH, Bethesda, Maryland, June 24-25, 2002, p.43.

148.          Kermis H., Kostov Y., Harms P., Rao G. (2002) Dual Excitation ratiometric Fluorescent pH sensor: Application to non-invasive bioprocess monitoring. BECON 2002: Sensors for biological research and medicine. NIH, Bethesda, Maryland, June 24-25, 2002, p.49.

149.          Rao G., Harms P., Kostov Y., Kermis H., Tolosa L., Gupta A. (2002) High throughput bioprocessing using non-invasive sensors. BECON 2002: Sensors for biological research and medicine. NIH, Bethesda, Maryland, June 24-25, 2002, p.67.

150.          Kostov, Y., Rao, G., (2002) Ratio measurements in oxygen determinations: wavelength ratiometry, lifetime discrimination and polarization detection. 6th European Conference on Optical Chemical Sensors and Biosensors EUROPT(R)ODE VI, Manchester, UK, 7 - 10 April 2002

151.          Rao, G., Harms, P.,  Kostov, Y., Kermis, H., Tolosa, L., Gupta, A. (2002) High throughput bioprocessing using non-invasive sensors. Cell culture engineering VIII, April 1-6, 2002, Snowmass, Colorado.

152.          Harms P., Kostov, Y., Rao G. (2001) Fluorescence-based glucose sensors. 221 National meeting of ACS, Division Analytical Chemistry, San Diego, No.71

153.          Kostov, Y., Harms P., Rao G. (2001) Low-cost oxygen sensing using unfiltered fluorescence. 221 National meeting of ACS, Division Analytical Chemistry, No. 93

154.          Kramer, S. F., Rao, G., Kostov, Y. and Bentley, W. E. (2000). Optimizing Harvest Time of Trichoplusia ni Larvae Using an Online GFP Optical Probe. AIChE. Los Angeles, CA

155.          Kostov, Y., Rao, G. (2000) Low-cost fluorescence sensors for biotechnology . Gordon Research Conference on Bioanalytical sensors, Proctor Academy, Andover, New Hampshire, July 23rd - 28th, 2000

156.          Kostov, Y., Scheper, T. (1998) Approaches to on-line correction of the oxygen luminescent sensor’s output. Europt(r)ode IV, Muenster, Germany, p. 227.

157.          Petrov, V., Kostov, Y., Tzonkov, S. (1993) Self-calibrating multichannel termometer for bioprocess measurements. National conference “Automation ‘93”, October 18-19, 1993. p 88.

158.          Petrov, V., Kostov, Y., Tzonkov, S. (1993) Device for automated data collection from photometrical absorption transducers. Commemorative session “40 years VIHVP”, Plovdiv, Bulgaria, 1993, p 136.

159.          Kostov, Y., Tzonkov, S., Petrov, V. (1993) Transducer for optical absorption-based sensors for conrol of biotechnological parameters. International Spring School’ 93 “Modelling and control of biotechnological parameters”, Sofia, Bulgaria, May 2-9, 1993, p 257

160.          Kostov Y., Tzonkov S. (1992) Optical methods and sensors using immobilized reagents for measurements of chemical concentrations. Fifth national conference “Process control ‘92“, Sofia, Bulgaria, September 10-11, 1992