Nucleic
acids are also irregular macromolecules
While
proteins are the workhorses of the cell, catalyzing most of its chemical
reactions, nucleic acids are the information storehouses of the cell.
Nucleic
acids come in two forms, ribonucleic acid (RNA) and deoxyribonucleic acid
(DNA). DNA is a permanent form of genetic information because the molecule
is chemically extremely stable.
RNA
is an impermanent form of nucleic acid since it is rapidly destroyed in
the cell. While DNA is the repository of genetic information passed from
one generation to the next, RNA is a messenger molecule which allows the
instructions in the DNA to be used in specifying the sequence of the proteins
to be expressed in the cell.
Nucleic
acids are made of monomers called nucleotides.
Arguably,
the most familiar nucleotide is adenosine triphosphate (ATP) which we
will see is extremely important as a molecule used to store chemical
energy.
Nucleotides are made up of three parts:
One to three phosphate groups (AMP, ADP, and ATP have 1, 2, and 3 phosphates,
respectively), a sugar, ribose in RNA and deoxyribose in DNA and a planar
molecule called a "base".
Bases
themselves come in five kinds of two general types. Bases can be pyrimidines
(consisting of one six member ring). Examples of these are cytosine
(C), thymine (T), or uracil (U). Thymine is a modified form of uracil
which is found in DNA; uracil is only found in RNA. Bases can also be
purines (consisting of fused six and five member rings)-purines are
either guanine (G) or adenine (A).
RNA
consists of a linear arrangement of these nucleotides joined by phosphate
groups linking successive ribose sugars. DNA consists of two strands
of nucleotides, running in opposite directions, and interacting by hydrogen
bonding between sets of pyrimidines and purines. A hydrogen-bonded pair
of nucleotides is called a "base pair", and G will only base
pair with C, and A with T.
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