Dr. Bradford E. Peercy, Ph.D.
Associate Professor
Department of Mathematics and Statistics
University of Maryland, Baltimore County
1000 Hilltop Circle
Baltimore, MD 21250

email: bpeercy at umbc dot edu

phone: 410-455-2436
fax: 410-455-1066


Academic History

I graduated from the University of Utah with a Ph.D. in Mathematics in 2003. I was a Pfeiffer-VIGRE Instructor at Rice University until 2006. I was a Research Associate at the Laboratory of Biological Modeling at NIH until 2008 when I became an Assistant Professor at UMBC. I am currently an Associate Professor in the Mathematics and Statistics Department at UMBC.

Research Interest

My research focus is on using mathematical techniques and modeling to solve biological (typically physiological) problems.

Current Research Funding

NSF-NIH (DMS-NIGMS) Hybrid mathematical modeling for cell fate determination in clustered cell migration, (#1953423), 2020-2023, $372,258
co-PI Michelle Starz-Gaiano, with co-I Matthias Gobbert and co-I Tagide deCarvalho

Publications

  1. β Janita Patwardhan HoganG and Bradford E. Peercy, Flipping the Switch: Islet Desynchronization through Cell Silencing. (in revision, 2020)

  2. Alyssa BerezG, Bradford E. Peercy, Michelle Starz-Gaiano, Development and Analysis of a Quanitative Mathematical Model of Bistability in the Cross Repression System between APT and SLBO within the JAK/STAT Signaling Pathway (accepted Systems Biology of Cell Signaling in Frontiers of Physiology, 2020)

  3. Bradford E. Peercy, Michelle Starz-Gaiano, Clustered cell migration: Modeling the model system of Drosophila border cells. Seminars in Cell & Developmental Biology, (2020). [Pubmed]

  4. β Janita PatwardhanG and Bradford E. Peercy, Network Analysis Applied to Pancreatic Islets. In Book: Systems Medicine: Integrative Qualitative and Computational Approached, (accepted 2019 - to be published Sept 1, 2020), Elsevier.

  5. # Bradford E. Peercy, Martin F. Schneider, Mathematical Modeling of Nuclear Trafficking of FOXO Transcription Factors. In Book: FOXO Transcription Factors: Methods and Protocols, 2019. Springer New York, 205-217. [Pubmed]

  6. Carlos BarajasG, Matthias K. Gobbert, Gerson KroizU, , and Bradford E. Peercy, Challenges and Opportunites for the Simulation of Calicum Waves on Modern Multi-Core and Many-Core Parallel Computing Platforms. International Journal for Numerical Methods in Biomedical Engineering, accepted (2019)

  7. Zach MekusU, Jessica CooleyU, Aaron GeorgeU, Victoria SaboU, Morgan StrezgowskiG, Michelle Starz-Gaiano, and Bradford E. Peercy, Effects of cell packing on chemoattractant distribution within a tissue. AIMS Biophysics, 2018 Jan 31; 5(1):1-21. [PDF]

  8. β Bradford E. Peercy, Richard Bertram, Arthur S. Sherman, Modeling of Glucose-Induced cAMP Oscillations in Pancreatic β Cells: cAMP Rocks when Metabolism Rolls, Biophysical Journal,2015 Jul 21;109(2):439-49. [Pubmed]

  9. Lathiena ManningG, Ann Marie WeidemanU, Bradford E. Peercy, Michelle Starz-Gaiano, Tissue landscape alters morphogen signaling during Drosophila egg development, Nature Communications, 2015 Jun 17;6:7356. [Pubmed]

  10. David P. StonkoG, Lathiena ManningG, Michelle Starz-Gaiano, Bradford E. Peercy, A mathematical model of collective cell migration in a three-dimensional, heterogeneous environment, PLoS ONE, 2015 Apr 13;10(4):e0122799. [Pubmed]

  11. β Samuel KhuvisG, Matthias K. Gobbert, Bradford E. Peercy, Time-Stepping Techniques to Enable the Simulation of Bursting Behavior in a Physiologically Realistic Computational Islet, Mathematical Biosciences. 2015 263:1-17.[Pubmed]

  12. β Gemma GearhartU, Shuai JiangU, Thomas J. MayU, Jane PanU, Samuel KhuvisG, Matthias K. Gobbert, Bradford E. Peercy, and Arthur Sherman. Dynamics of Computational Islet Simulations: Islets with Majority Mutated Open KATP Channels Retain Bursting. Letters in Biomathematics, vol. 1, no. 1, 13 pages, 2014. [Invited paper for the inaugural issue of this journal, published originally in the Proceedings of the Sixth Symposium on BEER 2013.][PDF]

  13. # Yewei Liu*, Robert Wimmer*G, Tova SchachterG, Tiansheng Shen, David S. StonkoG, Bradford E. Peercy, Martin F. Schneider, Modeling Foxo1-GFP nuclear cytoplasmic fluxes reveals that IGF1 markedly increases fractional phosphorylation of Foxo1 in skeletal muscle fiber nuclei. American Journal of Physiology-Cell Physiol, 2014 Mar 15;306(6):C570-84. *- these authors contributed equally.[Pubmed]

  14. Zana CoulibalyG, Bradford E. Peercy, Matthias K. Gobbert, Insight into Spontaneous Recurrent Calcium Waves in a 3-D Cardiac Cell Based on Analysis of a 1-D Deterministic Model, International Journal of Computer Mathematics, May 9, 2013.[IJCM]

  15. Gregory HandyU, Bradford E. Peercy, Extending the IP3 Receptor Model to Include Competition with Partial Agonists, Journal of Theoretical Biology, (2012) Oct 7;310:97-104.[Pubmed]

  16. Ď Rene F. Chun, Bradford E. Peercy, John S. Adams, Martin Hewison, Vitamin D binding protein and monocyte response to 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D: Analysis by mathematical modeling, PLoS ONE, (2012), 7(1):e30773.[Pubmed]

  17. β Bradford E. Peercy, Arthur Sherman, How Pancreatic Cells Discriminate Long- and Short-Time Scale cAMP Signals, Biophysical Journal, 2010, 99(2), 398-406.[Pubmed]

  18. β Min Zhang, Bernard Fendler, Bradford E. Peercy, Pranay Goel, Richard Bertram, Arthur Sherman, Leslie Satin, Synchronization of Islet Calcium Oscillations by Cholinergic Stimulation, Biophys. J. 1008 0: biophysj.107.125088. [PubMed]

  19. Bradford E. Peercy, Initiation and Propagation of an Intracellular Neuronal Calcium Wave, J. Comput. Neurosci. 2008 Oct;25(2):334-48. [PubMed]

  20. Bradford E. Peercy, Steven J. Cox, Sagit Shalel-Levanon, Ka-Yiu San, George Bennett, A Kinetic Model of Oxygen Regulation of Cytochrome Production in Escherichia coli, J Theor Biol, 2006 Oct 7;242(3):547-63. [PubMed] [JTB]

  21. S.J. Cox, S.S. Levanon, A. Sanchez, H. Lin, B. Peercy, G.N. Bennett and K-Y. San, Development of a metabolic network design and optimization framework incorporating implementation constraints: a succinate production case study, Metabolic Engineering, vol. 8, (2006), p. 46-57. [PubMed]

  22. Bradford E. Peercy, J.P. Keener, Coupled Cell Model of Border Zone Arrhythmias, SIAM Journal of Applied Dynamical Systems, (2005) Vol 4, Num. 3, pp. 679-710. [SIADS]

  23. R.D. Vaughn-Jones, B. E. Peercy, J.P. Keener, K.W. Spitzer, Intrinsic H+ Ion Mobility in the Rabbit Ventricular Myocyte, Journal of Physiology, (2002) 541.1, pp. 139-158. [PubMed]

  24. K.W. Spitzer, R.L. Skolnick, B.E. Peercy, J.P. Keener, R.D. Vaughn-Jones, Facilitation of Intracellular H+ Ion Mobility by CO2/HCO-3 in Rabbit Ventricular Myocytes Is Regulated by Carbonic Anhydrase , Journal of Physiology, (2002) 541.1, pp. 159-167. [PubMed]

  25. J. Alford, N. Cogan, C. Miller, S. Patinkin, B.E. Peercy, N. A. Rosenberg, Boundary Element Analysis of Intracardiac Electrogram Sensing, IMA Preprint Series #1589-3, 1998. [IMA (pdf)]
G- Graduate student, U- Undergraduate student

⊙-Clustered cell migration , β-cells and islets , #-Muscle signaling, ♥-Cardiac , Ď-Vitamin D, ⤛-Neuronal , ⨻-Facultative Anarobes

Some More Details of Less Current Research