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Research Interest (2002-2008):
My research interest is in characterizing global
molecular and physiological events of microbial systems via systems biological
approach. I'm a member of Dr. Mark R.
Marten's Group, where our system of choice is Aspergillus
nidulans
and other relevant and beneficial filamentous fungi. Our main tool of
analysis is comparative proteomics via two-dimensional gel electrophoresis and
mass spectrometric identification of proteins of interest, through which we
not only acquire a panoptic snapshot of functional-level changes in the cells,
but also assign probable functions to novel and/or hypothetical proteins. The
biological question we are currently addressing is how fungi adapt to
stressful conditions, including conditions of elevated salt concentration,
carbon-starvation, and the presence of antibiotics.
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Aspergillus nidulans wildtype intracellular 2DE proteome
map
(pI 4-7, Mr 15-200 kDa)
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Aspergillus nidulans mutant intracellular 2DE proteome
map
(pI 3-11 NL, Mr 15-200 kDa)
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Publications:
23.
Klionsky DJ et al. (2012)
Autophagy, "Guidelines for the use and interpretation of assays for monitoring autophagy"
[Pubmed]
22.
Kim Y*, Islam N, Moss BJ, Nandakumar MP, Marten MR (2011)
Biotechnol Bioeng, "Autophagy induced by rapamycin and carbon-starvation have
distinct proteome profiles in Aspergillus." (* corresponding)
[Pubmed]
21.
Kim Y, Nandakumar MP, Marten MR (2008)
Brief Func Genom Proteom, "The state of proteome profiling in the fungal genus
Aspergillus."
[Pubmed]
20.
Moss BJ, Kim Y, Nandakumar MP, Marten MR (2008)
Biotechnol Prog, "Quantifying metabolic activity of filamentous fungi using a
colorimetric XTT assay."
[Pubmed]
19.
Kim Y, Nandakumar MP, Marten MR (2007)
Trends in Biotechnol, "Proteomics of filamentous fungi."
[Pubmed]
18.
Kim Y, Nandakumar MP, Marten MR (2007)
Fungal Genet and Biol,
"Proteome map of Aspergillus nidulans during osmoadaptation."
[Pubmed]
Other Publications:
17.
Jo MY, Kim YG, Kim Y*, Lee SJ, Kim MH, Joo KM, Kim HH, Nam DH (2012)
Mol Med Report, "Combined therapy of temozolomide and ZD6474 (vandetanib) effectively reduces glioblastoma tumor volume through
anti-angiogenic and anti-proliferative mechanisms."
[Pubmed]
16.
Jung Y, Joo KM, Seong DH, Choi YL, Kong DS, Kim
Y, Kim MH, Jin J, Suh YL, Seol HJ, Shin CS, Lee JI, Kim JH, Song
SY, Nam DH (2012)
Intl J Oncol, "Identification of prognostic biomarkers for glioblastomas using
protein expression profiling."
[Pubmed]
15.
Kim Y*, Kim KH*,
Lee J, Lee YA, Kim M, Park K, Lee SJ, Yang H, Jin J, Joo KM, Lee J, Nam DH (2012)
Lab Invest, "Wnt implicated glioblastoma radioresistance."
(* equal contribution)
[Pubmed]
14.
Seol HJ, Yoo HY, Jin J, Joo KM, Kim HS, Yoon SJ, Choi SH,
Kim Y,
Pyo HR, Lim DH, Kim W, Um HD, Kim JH, Lee JI, Nam DH (2011)
Oncol Res, "The expression of DNA damage checkpoint proteins and prognostic
implication in metastatic brain tumors."
[Pubmed]
13.
Jin J, Bae KH, Yang H, Lee SJ, Kim H, Kim
Y, Joo KM, Park TG, Nam DH (2011)
Bioconjug Chem, "In vivo specific delivery of c-Met siRNA to glioblastoma
using cationic solid lipid nanoparticles."
[Pubmed]
12.
Seol HJ, Jin J, Seong DH, Joo KM, Kang W, Yang H, Kim J, Shin CS,
Kim Y,
Kim KH, Kong DS, Lee JI, Aboody KS, Kim SU, Nam DH (2011)
Cancer Lett, "Genetically engineered human neural stem cells with rabbit
carboxyl esterase can target brain metastasis from breast cancer."
[Pubmed]
11.
Kim KH, Yoo HY, Joo KM, Jung Y, Jin J, Kim Y, Yoon SJ, Choi SH, Seol HJ, Park WY, Nam DH (2011)
Exp Med Mol, "Time-course analysis of DNA-damage response-related genes after in vitro radiation in H460 and H1229 lung cancer cell lines."
[Pubmed]
10.
Lee SJ*, Kim Y*, Jo MY, Kim HS, Jin Y, Kim SU, Jin J, Joo KM, Nam DH (2011)
Oncol Rep, "Combined treatment of tumor-tropic human neural stem cells
containing suicide gene effectively target brain tumor provoking mild immune
response"
(* equal contribution)
[Pubmed]
9.
Jin J, Joo KM, Lee SJ, Jo MY, Kim Y, Jin Y, Kim JK, Ahn JM, Yoon MJ, Lim J, Nam DH (2011)
Oncol Rep, "Synergistic therapeutic effects of cytokine-induced killer cells and temozolomide against glioblastoma"
[Pubmed]
8.
Kim Y, Joo KM, Jin J, Nam DH (2009)
Intl J Stem Cells, "Cancer stem cells and their mechanism of chemo-radiation resistance."
7.
Kim Y, Egan GL, Deorkar N (2003)
LC-GC North America, "Solid phase extraction separation of desired analytes based on hydrophobicity of SPE sorbent."
6.
Fried B, LaTerra R, Kim Y (2002)
J of Helminthol,
"Emergence of cercariae of Echinostoma caproni and
Schistosoma mansoni from Biomphalaria glabrata under different
laboratory conditions."
[Pubmed]
5.
Fried B, LaTerra R, Kim Y (2002)
Korean J Parasitol, "Effects of exogenous glucose on survival and infectivity
of Schistosoma mansoni cercariae."
[Pubmed]
4.
Fried B, Kim Y (2002)
"Effects of larval Echinostoma caproni and Schistosoma mansoni infection on the heart rate of Biomphalaria glabrata snails."
3.
Kim Y, Fried B, Sherma J (2002)
The Veliger, "Thin layer chromatographic analysis of lutein and beta-carotene in
Biomphalaria glabrata maintained on a high fat diet."
2.
Wagner SD, Kim Y, Fried B, Sherma J (2001)
J of Planar Chromato-Modern TLC,
"Thin-layer chromatographic analysis of glucose, maltose, and raffinose in
Biomphalaria glabrata (gastropoda) infected with Echinostoma
caproni (trematoda)."
1.
Kim Y, Fried B, Sherma J (2001)
J of Planar Chromato-Modern TLC, "Thin-layer chromatographic analysis of
carbohydrates in Biomphalaria glabrata snails maintained on a high-fat
diet."
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