Yonghyun (John) Kim

Yonghyun (John) Kim, PhD
http://www.umbc.edu/~yk1
yk1 [at] umbc [dot] edu
Class of 2008
Chemical and Biochemical Engineering
University of Maryland, Baltimore County (UMBC)*
Full curriculum vitae available upon request.
* Currently at Samsung Biomedical Research Institute


Research Interest:

My current research interest is in characterizing global molecular and physiological events of microbial systems via systems biological approach. I'm a member of Dr. Mark R. Marten's Group, where our system of choice is Aspergillus nidulans and other relevant and beneficial filamentous fungi. Our main tool of analysis is comparative proteomics via two-dimensional gel electrophoresis and mass spectrometric identification of proteins of interest, through which we not only acquire a panoptic snapshot of functional-level changes in the cells, but also assign probable functions to novel and/or hypothetical proteins. The biological question we are currently addressing is how fungi adapt to stressful conditions, including conditions of elevated salt concentration, carbon-starvation, and the presence of antibiotics.

A.nidulans 2DE pI 4-7
Aspergillus nidulans wildtype intracellular 2DE proteome map
(pI 4-7, Mr 15-200 kDa)

A.nidulans 2DE pI 3-11 NL
Aspergillus nidulans mutant intracellular 2DE proteome map
(pI 3-11 NL, Mr 15-200 kDa)

Publications:

1.    Kim Y, Nandakumar MP, Marten MR (2008) Brief Func Genom Proteom, "The state of proteome profiling in the fungal genus Aspergillus." [Pubmed]

2.    Moss BJ, Kim Y, Nandakumar MP, Marten MR (2008) Biotechnol Prog, "Quantifying metabolic activity of filamentous fungi using a colorimetric XTT assay." [Pubmed]

3.    Kim Y, Nandakumar MP, Marten MR (2007) Trends in Biotechnology, "Proteomics of filamentous fungi." [Pubmed]

4.    Kim Y, Nandakumar MP, Marten MR (2007) Fungal Genetics and Biology, "Proteome map of Aspergillus nidulans during osmoadaptation." [Pubmed]

5.    Fried B, Kim Y (2003) Veliger, "Effects of larval Echinostoma caproni and Schistosoma mansoni infection on the heart rate of Biomphalaria glabrata snails."

6.    Fried B, LaTerra R, Kim Y (2002) J of Helminthol, "Emergence of cercariae of Echinostoma caproni and Schistosoma mansoni from Biomphalaria glabrata under different laboratory conditions." [Pubmed]

7.    Fried B, LaTerra R, Kim Y (2002) Korean J Parasitol, "Effects of exogenous glucose on survival and infectivity of Schistosoma mansoni cercariae." [Pubmed]

8.    Kim Y, Fried B, Sherma J (2002) Veliger, "Thin layer chromatographic analysis of lutein and beta-carotene in Biomphalaria glabrata maintained on a high fat diet."

9.    Wagner SD, Kim Y, Fried B, Sherma J (2001) J of Planar Chromato-Modern TLC, "Thin-layer chromatographic analysis of glucose, maltose, and raffinose in Biomphalaria glabrata (gastropoda) infected with Echinostoma caproni (trematoda)."

10.  Kim Y, Fried B, Sherma J (2001) J of Planar Chromato-Modern TLC, "Thin-layer chromatographic analysis of carbohydrates in Biomphalaria glabrata snails maintained on a high-fat diet."