INTRODUCTION TO BIOMEDICINAL CHEMISTRY

[Credits: CHEM 455 (3-4 Cr); CHEM 655 (3 Cr)]
 

INSTRUCTOR: DR. HOSMANE

Office: Chemistry 502 Phone: x2520
 
 

Course Description: A survey of (a) principles and methods of drug design, including modern rational approach aided by computers, disease models, natural products, analogue synthesis, and pharmacophore identification, (b) physicochemical principles of drug action, including solubility, partition coefficients, surface interactions, stereochemical, electronic, and quantum chemical factors, chemical bonding, and quantitative structure-activity relationships (QSAR), (c) receptor concept of drug action, including nature, definition, characterization, models, and classical theories of receptor function, (d) mechanisms of drug action, including enzyme stimulation, inhibition, and regulation, (e) drug distribution, metabolism, and inactivation, including bioavailability, biotransformations, chemical and metabolic stability, pharmacokinetic variability, and design of prodrugs, (f) case studies selected from a list of antitumor, analgetic, antimicrobial, anticholinergic, antiadrenergic, psychoactive, and cardiovascular drugs, and (g) current status and future impact in drug development, including protein therapeutics, gene therapy, antisense drugs, cytokines, and drug resistence

Prerequisite: Biol 100, CHEM 352 or Equivalent