WELCOME TO
THE HOME PAGE OF
Dr. Ramachandra S.
Hosmane
Professor of Chemistry
(UMBC)
(Click the photo for more recent pictures of RSH)
Personal data:
Born in Gokarn (
Family: Wife,
Raji; Daughter: Mala
Citizenship: United States
Education:
B.Sc. 1966; M.Sc. 1968 - Karnataka
University (India)
M.S. 1976; Ph.D. 1978 -
University of South Florida (U.S.A.)
Experience in Higher
Education:
1994-Present: Professor of
Chemistry, University of
1986-1994:
Associate Professor of Chemistry, UMBC
1982-1986:
Assistant Professor of Chemistry, UMBC
1979-1982:
Postdoctoral Res. Assoc.,
Recent Awards and Honors:
2009-2012:
Presidential Teaching Professor
2002:
from American Chemical Society,
2000-2001:
Outstanding Educator of the Year Award
from
1998-2001:
Presidential Research Professor
1999:
Honorary Faculty Member, Golden Key National Honor Society
1996:
Outstanding
Historical Record of Grant Support:
(41) National Institutes of Health (NIGMS, #1R01GM087738) Inhibition of HCV as an Opportunistic HIV Co-infection, 2008-12
(40) American
Heart Association (#AHA 0755372U), Artificial Blood Based
on Hemoglobin Dendrimers, 2007-09
(39) North
American Biologicals, Inc. (Nabi) , Ring-Expanded
Nucleosides & Nucleotides, 1999-09
(38) National
Institutes of Health (NIAID, #R21AI071802), Mechanistic
Studies of Anti-HIV Activity, 2006-09
(37)
(36) National
Institutes of Health (NIAID, #R01AI55452), “Fat”
Nucleosides & Nucleotides, 2002-07
(35) Grace
Chemical Co., Synthesis of Novel
Thiophene Analogues for Artificial Membranes, 2004-05
(34) National
Institutes of Health (NHLBI, #R01HL48632), Novel
Org. Reagents for Biomed. Appls, 1999-03
(33) National
Institutes of Health (NHLBI, #R01HL48632-S1), Res. Suppl. Minority Undergrad. Asst., 2000-02
(32) Transbio
Corp., Synthesis of a Novel Heterocycle
for Sensitive Detn. of Proteins & Nucl. Acids, 2001-01
(31) Novadaq
Corp.,
(30) National
Institutes of Health ((NCI, #R01 CA71079),“Fat”
& “Slim” Nucleosides & Nucleotides, 1996-00
(29) National
Institutes of Health ((NCI, #R01 CA71079-S1), Res. Suppl. Minority Undergrad. Asst.,1997-00
(28)
(27) National
Science Foundation (Whalen, P. I.), High
Field NMR Inter. Data Anal. & Modeling, 1996-98
(26) National
Institutes of Health (NHLBI, #R01 HL33629), Novel
Org. Reagents for Biomed. Appl., 1994-97
(25)
(24) National
Institutes of Health (NIGMS, #R01 GM49249), Novel
Antiretroviral Nucleo(s/t)ides, 1992-96
(23)
Boehringer-Mannheim Corp., Novel
Heterocycles as Potential Therapeutic Agents, 1991-96
(22) National
Institutes of Health (NIGMS, #R01 GM49249), Res.
Suppl. Minority Grad. Asst., 1992-95
(21)
(20)
Rhone-Poulenc, Novel Heterocycles as
Potential Agricultural Chemicals, 1991-95
(19)
(18)
Martin-Marietta Laboratories, Synthesis
of Photochromes for Holograms & Sensor Protection , 1993-94
(17) Autodesk,
Inc., Design & Synthesis of Novel
Organic Molecules for Biomedical Applications, 1992-93
(16) Burns
Laboratories, Inc., Altered Nucleoside
with Potential for AIDS Therapy, 1991-1993
(15) Burns
Laboratories, Inc., Human Hemoglobin
Cross-Linking Reagents, 1991-93
(14) National
Institutes of Health (P.I. G. Rosen, UMB), Synthesis
of Heterocyclic Spin Labels, 1990-92
(13) National
Institutes of Health (NCI, #1R01 CA36154), “Fat”
Nucleosides & Nucleotides, 1987-91
(12) Dow-Elanco
Co., Novel Organics for Agricultural and
Biomedical Applications, 1987-91
(11) Am. Cancer
Soc.(MD Progr.), Is There a Correln bet.
Conformn. & Activity of Nucleo(s/t)ides?, 1989-90
(10) Cytel
Corporation, Biological Screening of
Potential Immune Modulating Agents, 1989-90
(09) Monsanto
Agricultural
(08) E. I. du Pont
de Nemours &
(07) American
Heart Assoc., MD Affiliate, Inc., Synthetic
Reagents to Cross-Link Hemoglobin, 1987-89
(06) Eli Lilly
&
(05) National
Institutes of Health (NHLBI, E. Bucci, P.I.), Hemoglobin-Based Oxygen Carriers, 1985-88
(04) Shell
Development Company, Novel Compounds for
Potential Agricultural Applications, 1985-86
(03) National
Institutes of Health (NCI, #R01 CA36154), Synthetic
Analogues of Coformycin, 1984-87
(02) Project SEED,
Am. Chem. Soc., Summer Educational
Experience for the Disadvantaged, 1983-00.
(01) Petroleum
Research Fund, American Chemical Society, Total
Synthesis of Coformycin, 1983-85
Current Professional
Activities:
Editorial Activities: Managing Editor, Frontiers in
Bioscience; current Topics in Medicinal Chemistry; Regional Editor, Molecules.
Panel
Membership: Recent Grant
Proposal Review Panels:
(1) Panel Member, NIH AIDS Discovery
& Development Study Section [ADDT], 2002-2006
(2) Ad Hoc Member, NIH AIDS SBIR/STTR
Study Section [AARR-E], 2002-2004
(3) Ad Hoc Member, NIH Drug Discovery,
Development, and Delivery Study Section [SSS-L], 2004
(4) Ad Hoc Member, NIH Biodef. &
Emerg. Infect. Diseases Study Sect. [ZAI 1 RCG-M (M2)], 2004
(5) Ad Hoc Member, NIH Hematology
Bioengineering Study Section [ZRG1 HEME-D 50], 2005
(6) Ad Hoc Member, NIH Bioengineering
Partnership Study Section [ZRG1-HEME-C-50R], 2006
(7) Ad Hoc Member, NIH RAID (Rapid
Access to Intervention Development) Review Panel, 2006
(8) Ad Hoc Member, NIH Discov.
& Develop. Program Proj. (P01) Special Emphasis Panel, 2006
(9) Ad Hoc Member, NIH Program Project
(P01), Blood Substitutes, Special Emphasis Panel, 2007
(10) Ad Hoc Member, NIH Co-op. Res.
Partnership on Influenza (U01), Special Emph. Panel, 2007
(11) Ad Hoc Member, NIH AIDS Discovery
& Develop. Special Emph. Panel (ZRG1-AARR-D), 2007
(12) Ad Hoc Member, FDA Site Visit Review
Panel, Office of Biotechnology Products,
(13) Ad Hoc Member, NIH AIDS Program Proj.
& Center Grants Review Panel (ZRG1-AARR-A), 2007
(14) Ad Hoc Member, NIH AIDS Program
Proj. (P01) Grants Rev. Panel [ZRG1 AARR-A (40)], 2007
(15) Ad Hoc
Member, NIH Co-op. Res. Partnership in
Biodefense, Special Emphasis Panel, 2007
(16) Ad Hoc Member,
NIH Program Project (P01), Blood Substitutes, Sp.Emph.Panel, 2008
(17) Ad Hoc
Member, NIH Minority Biomedical Res. Support (MBRS) Program in
Chemistry, 2008
(18) Ad Hoc
Member, NIH AIDS Progr. Proj. (P01) Rev.
Panel [ZRG1 AARRA (40)], 2008
(19) Ad Hoc
Member, NIH RAID (Rapid Access to
Intervention Development) Review Panel, 2008
(20) Ad Hoc
Member, NIH Diversity Fellowship Review Panel (ZRG1 SBIB-V (29)L)), 2009
(21) Ad Hoc
Member, NIH/NHLBI Special Review Committee on Transfusion Medicine, 2009
(22) Ad Hoc
Member, NIH/NIAID Challenge Grants Review Panel, 2009
Peer Reviewer: Grant Proposals:
PRF, NIH, NSF, Am. Heart Assoc., Res. Corp., Guggenheim Foundation; Journals:
JACS, JOC, Tet. Lett., J.Het.Chem., J. Med. Chem., Synthesis, Chem. Ber.,
Liebigs Ann. Chem., Nucleosides & Nucleotides, Nucl. Acids Res., J.
Biomol.Struct. Dyn., Tetrahedron, Angewandte Chemie, Eur. J. Org. Chem.,
Hemoglobin, Bioorg. Med. Chem., Bioorg. Med. Chem. Lett.
Memberships: Sigma Xi; Affiliate IUPAC, Am. Chem. Soc.,
Chem. Soc.(
My Research Interests
My research interests areBiomedicinal Chemistry with applications inantiviral and anticancer therapy, as well asBiomedical
Technology with
applications inartificial
blood. Our research, in general, involves
computer-assistedmolecular
modeling,organic synthesis,,biochemical & biophysical studies, and physiological & biological screening. The two specific current
areas of research interests include:
(A) "Fat"
Nucleosides and Nucleotides as Potential Anticancer and Antiviral Agents:These novel ring-expanded ("fat")
nucleoside/nucleotide analogues, designed and synthesized in this lab, have
been 
found to be potent, broad-spectrum anticancer and antiviral agents
with little, if any, toxicity to the host. Our current focus is on
prostate and breast cancers, as well as on West
(B) Artificial Blood for
Emergency Transfusions:
One of our research areas
focuses on developing substitutes for human blood for emergency
transfusions. In view of the current world events engulfed in terrorism
and wars, the need for a blood substitute is becoming 
increasingly pressing. The scarcity of
blood for emergency transfusions, especially when rare types are needed, the
possible transmission of diseases associated with blood transfusion such as
AIDS and hepatitis, the limitations on storage stability of intact blood, the
necessity for blood typing before transfusion, and not to mention the ancillary
religious reasons for non-acceptance of donated blood by certain ethnic
individuals, give compelling impetus to pursue an alternative for whole blood.
To this end, we are involved in computer-aided design and chemical
synthesis of novel polyfunctional organic reagents to cross‑link
hemoglobin (see Fig. 2). The modified cell-free hemoglobins
are to be used in emergency transfusions with no necessity to type or
cross-match the patient’s blood and with no fears of transmission of
blood-borne diseases. The covalently cross-linked hemoglobins are
supposed to overcome the two major problems associated with cell-free
hemoglobins, including their quick elimination by kidneys, and their too high
oxygen affinity that prevents adequate oxygen transport from lungs to tissues.
My Selected Recent Research Publications
R. S. Hosmane and J. F. Liebman, "Paradoxes and Paradigms: Why is Quinoline Less Basic than Pyridine or Isoquinoline? A Classical Organic Chemical Perspective,” Struct. Chem. 2009, 20, 693-697.
R. S. Hosmane, "Ring-Expanded ("Fat") Purines and Their Nucleoside/Nucleotide Analogues as Broad-Spectrum Therapeutics, ” Progr. Heterocycl. Chem. 2009, 21, 35-68.
R. Kumar, R. K. Ujjinamatada, and R. S. Hosmane
” The First Synthesis of a Novel 5:7:5-Fused Diimidazodiazepine Ring System and Some of Its Chemical Properties, ” Org. Lett. 2008, 10, 4681-4684.
V. S. R. K.
Yedavalli, N. Zhang, P. Zhang, H. Cai, M. F. Starost, R. S. Hosmane, and K-T.
Jeang, ” Ring-Expanded (REN) Nucleoside Analogues Inhibit RNA Helicase and
Intracellular HIV-1 Replication, ” J.
Med. Chem. 2008, 51, 5043-5051.
R. K.
Ujjinamatada, P. Phatak, A. M. Burger, and R. S. Hosmane, “Inhibition of
adenosine deaminase by analogues of adenosine and inosine incorporating a
common heterocyclic base, 4(7)-amino-6(5)H-imidazo[4,5-d]pyridazin-7(4)one,” J. Med. Chem. 2008, 51, 694-698.
P. Zhang, N. Zhang, V. Buckwold,
R. S. Hosmane, “Chemical and biological effects of substitution of the
2-position of ring-expanded (“fat”) nucleosides containing the imidazo[4,5-e][1,3]
diazepine-4,8-dione ring system: The role of electronic and steric factors on glycosidic
bond stability and anti-HCV activity,” Bioorg. Med. Chem., 2007,
15, 4933-4945.
R. K. Ujjinamatada, A. Baier, P.
Borowski, and R. S. Hosmane, “An analogue of AICAR with dual inhibitory
activity against WNV and HCV NTPase/helicase: Synthesis and in vitro
screening of 4-carbamoyl-5-
(4,6-diamino-2,5-dihydro-1,3,5-triazin-2-yl)imidazole-1-ß-D-ribofuranoside,” Bioorg.
Med. Chem. Lett. 2007, 17, 2285-2288.
P. Zhang, N. Zhang, B. E. Korba,
and R. S. Hosmane, “Structure-activity relationship studies on anti-HCV
activity of ring-expanded (‘fat’) nucleobase analogues containing the
imidazo[4,5-e][1,3]diazepine-4,8-dione ring system,” Bioorg. Med.
Chem. Lett. 2007, 17, 2225-2228.
R. K. Ujjinamatada, A. Bhan, and R. S. Hosmane, "Design of Inhibitors Against Guanase: Synthesis and Biochemical Evaluation of Analogues of Azepinomycin," Bioorg. Med. Chem. Lett. 2006, 16, 5551-5554.
R. K. Ujjinamatada, R.L. Paulman, R. G. Ptak, and R. S. Hosmane,
"Nucleosides with Self-Complementary Hydrogen-Bonding Motifs: Synthesis
and Base-Pairing Studies of Two Nucleosides Containing the Imidazo[4,5-d]pyridazine
Ring System," Bioorg. Med. Chem. 2006, 14, 6359-6367.
P. Zhang, N. Zhang, B. E. Korba, and R. S. Hosmane, “Synthesis and In Vitro
Anti-Hepatitis B and C Virus Activities of Ring-Expanded ("Fat")
Nucleobase Analogues Containing the Imidazo[4,5-e][1,3]diazepine-4,8-dione
Ring System,” Bioorg. Med. Chem. Lett. 2005, 15,
5397-5401.
R. K. Ujjinamatada
and R. S. Hosmane, “Selective Functional Group Transformation Using Guanidne:
The Conversion of an Ester Group into an Amide in Vinylogous Ester-Aldehydes,” Tetrahedron
Lett. 2005, 46, 6005-6009.
R. K.
Ujjinamatada, Y. S. Agasimundin, P. Zhang, V. Koch, H. Schmitz, P.
Borowski, K. Kalicharran, A. Fattom, and R. S. Hosmane, “A Novel
Imidazole Nucleoside Containing a Diaminodihydro-s-Triazine as a
Substituent and an Inhibitory Activity against the West Nile Virus
NTPase/Helicase,” Nucleosides Nucleotides Nucleic Acids 2005, 24,
1775-1788.
Ujjinamatada, R. K., Agasimundin,
Y. S., Borowski, P., and Hosmane, R. S., “ Reactions of Guanidine with
Vinylogous Ester-Aldehydes: Synthesis and Anti-West Nile Virus Activity
of a Novel Imidazole Nucleoside Containing a Diaminodihydro-s-triazine
as a Substituent,” Antiviral Res. 2005, 65, A68-A69.
T. A. Roach, V. W. Macdonald, and
R. S. Hosmane, “A Novel Site-Directed Affinity Reagent for Cross-Linking Human
Hemoglobin: Bis[2-(4-phosphonooxy phenoxy)carbonylethyl]phosphinic Acid
(BPPCEP)” J. Med. Chem., 2004, 47, 5847-5859.
S. Gunther, M. Asper, C. Roser,
L.K.S. Luna, C. Drosten, B. Becker-Ziaza, P. Borowski, and R. S. Hosmane,
"Applications of Real-Time PCR for Testing Antivial Compounds Against
Lassa Virus, SARS CoronaVirus, and Ebola Virus In Vitro," Antiviral
Res. 2004, 63, 209-215.
A. Reayi and R. S.
Hosmane, “Inhibition of Adenosine Deaminase by Novel 5:7-Fused Heterocycles
Containing the Imidazo[4,5-e][1,2,4]triazepine Ring System: A
Structure-Activity Relationship Study,” J. Med. Chem. 2004, 47,
1044-1050.
A. Reayi and R. S. Hosmane,
"Inhibitors of Adenosine Deaminase: Continued Studies of
Structure-Activity Relationships in Analogues of Coformycin," Nucleosides
Nucleotides Nucleic Acids 2004, 23, 263-270.
R. S. Hosmane and J. F. Liebman,
“Resonance Stabilization in Diazophenoxides,” Struct. Chem. 2004,
15, 253-255.
N. Zhang, H.-M. Chen, V. Koch, H.
Schmitz, C.-L. Liao, M. Bretner, V. S. Bhadti, A. I. Fattom, R. B. Naso, R. S.
Hosmane, and P. Borowski, "Ring-Expanded Nucleoside and Nucleotide (REN)
Analogues Exhibit Potent In Vitro Activity Against Flaviviridae
NTPases/Helicases, including Those of the West Nile Virus (WNV), Hepatitis C
Virus (HCV), and Japanese Encephalitis Virus (JEV)," J. Med. Chem. 2003,
46, 4149-4164.
N. Zhang, H.-M. Chen, V. Koch, H.
Schmitz, C.-L. Liao, A. I. Fattom, R. B. Naso, K. Kalicharran, P. Borowski, and
R. S. Hosmane, "Potent inhibition of NTPase/helicase of the West Nile
Virus by Ring-Expanded Nucleoside (REN) Analogues," J. Med. Chem. 2003,
46, 4776 - 4789.
R. S. Hosmane, “Antiviral Agents,”
in Kirk-Othmer Encyclopedia of Chemical Technology, John Wiley &
Sons, New York, 2003 (invited article)
<http://www.mrw.interscience.wiley.com/kirk/articles/antireva.a01/bibliography-fs.html>
Borowski, P., zur Wiesch, J. C. R.
S., Schmitz, H., and Hosmane, R. S., “Inhibition of HCV NTPase/Helicase by
Ring-Expanded Nucleosides (RENs),” Hepatology 2003, 38,624A-625A.
F. N. Burnett and R. S. Hosmane,
"Synthesis of a Novel Ring-Expanded Purine Analogue Containing a 5:8-Fused
Imidazo[4,5-e][1,2,4]triazocine Ring System Amidst Opportunistic
Rearrangements and Ring Transformations," Tetrahedron 2002, 58,
9567-9578.
N. Zhang, H. -M. Chen, R. Sood, K.
Kalicharran, A. I. Fattom, R. B. Naso, D. L. Barnard, R. W. Sidwell, and R. S. Hosmane,
"In Vitro Inhibition of Measles Virus Replication by Novel
Ring-Expanded (“Fat”) Nucleoside Analogues Containing the
Imidazo[4,5-e][1,3]diazepine Ring System, Bioorg. Med. Chem. Lett.
2002, 12, 3391-3394.
R. Hosmane, "Ring-Expanded
("Fat") Nucleosides as Broad-Spectrum Anticancer and Antiviral
Agents," in "Current Topics in Medicinal Chemistry: Recent
Developments in Antiviral Nucleosides, Nucleotides, and Oligonucleotides,"
Hosmane, R. S., Ed., Bentham Science Publishers, 2002, Vol. 2, pp. 1093-1109.
R. Hosmane, "Coformycin and
Analogues as Inhibitors of Adenosine Deaminase," in "Modified
Nucleosides, Synthesis, and Applications," Loakes, D, Ed., Transworld
Research Network, Trivendrum, 2002; pp.133-151.
P. Borowski, M. Lang, A. Haag, H.
Schmitz, J. Choe, H. -M. Chen, and R. S. Hosmane, "Characterization of
Imidazo[4,5-d]pyridazine Nucleosides as Modulators of Unwinding Reaction
Mediated by West Nile Virus NTPase/Helicase: Evidence for Activity on the Level
of Substrate and/or Enzyme," Antimicrob. Agents Chemotherap. 2002,
46, 1231-1239.
R. K. Sood, V. S. Bhadti, A. I.
Fattom, R. B. Naso, H. Chen, B. E. Korba, E. Kern, and R. S. Hosmane,
"Novel Ring-Expanded Nucleoside Analogs Exhibit Potent and Selective
Inhibition of Hepatitis B Virus Replication in Cultured Human Hepatoblastoma
Cells," Antiviral Res., 2002,53, 159-164.
P. Borowski, A. Niebuhr, H.
Schmitz, R. S. Hosmane, M. Bretner, M. A. Siwecka, and T. Kulikowski,
"NTPase/Helicase of Flaviviridae: Inhibitors and Inhibition of the
Enzyme," Acta Biochem. Polon. 2002, 49, 597-614.
M. V. Roux, M. Temprado, J. Z.
Dávalos, P. Jiménez, R. S. Hosmane, and J. F. Liebman, "Enthalpy of
Formation of Methyl Benzoate: Calorimetry and Consequences," Phys.
Chem. Chem. Phys. 2002, 4, 3611-3613.
R. S. Hosmane and J. F. Liebman,
"Diazomethane and Ethyl Diazoacetate: The Role of Substituent Effects on
Stability," Struct. Chem. 2002, 5-6, 501-503.
H. -M. Chen and R. S. Hosmane,
"Synthesis of a Novel Ring-Expanded ("Fat") Nucleotide Analogue
of Phosphonomethoxyethylguanine (PMEG) Containing the
Imidazo[4,5-e][1,3]diazepine Ring System," J. Heterocycl. Chem. 2001,
38, 1313-1315.
L. Wang and R. S. Hosmane, "A
Unique Ring-Expanded Acyclic Nucleoside Analogue That Inhibits Both Adenosine
Deaminase (ADA) and Guanine Deaminase (GDA; Guanase): Synthesis and
Enzyme Inhibition Studies of 4,6-Diamino-8-H-1-hydroxyethoxymethyl-8-iminoimidazo[4,5-e][1,3]diazepine,
" Bioorg. Med. Chem. Lett. 2001, 11, 2893-2896.
H. -M. Chen and R. S. Hosmane,
"Synthesis of 1-(2'-O-Methyl-ß-D-ribo- furanosyl)-1H-imidazo[4,5-d]-
pyridazine-4,7(5H,6H)-dione: An Attractive Building Block for Antisense and
Triple-helical Applications," Molecules 2001, 6,
203-207.
J. Gill, M. Bretner, R. Newman, N.
Kyprianou, and R. S. Hosmane, "Synthesis, Anticancer Activity, and In
Vitro Mechanistic Investigations of Several "Fat" Nucleosides
Containing the Imidazo[4,5-e][1,3] diazepine Ring System," Nucleosides
& Nucleotides 2001, 20, 1043-1045.
H. -M. Chen and R. S. Hosmane,
"Acyclic Nucleoside/Nucleotide Analogues Bearing an Imidazole Ring
Skeleton," Nucleosides & Nucleotides 2001, 20,
1599-1614.
Z. Sun and R. S. Hosmane, "An
Improved Synthesis of 9-Benzyladenine: A Model for Adenosine and Its
Analogues," Synth. Commun. 2001, 32, 549-554.
R. K. Sood, V. S. Bhadti, H. -M.
Chen, and R. S. Hosmane, "6-Amino-1-(2'-deoxy-b-D-ribofuranosyl)-4,5-dihydro-8H-imidazo[4,5-e][1,3]diazepine-4,8-dione,"
Molecules2001, 6, M264.
H. -M. Chen and R. S. Hosmane,
"Synthesis of 1-(2'-Deoxy-ß-D-ribo- furanosyl)-1H-imidazo [4,5-d]-
pyridazine-4,7(5H,6H)-dione: a Potentially Useful Building Block for Antisense
Applications," Molecules 2000, 5, 1187-1193.
H. -M. Chen and R. S. Hosmane,
"Synthesis of a Novel Ring-Expanded Nucleoside Analogue Containing the
Imidazo[4,5-e][1,3]diazepine Ring System With a Guanidinocarbamoyl- Substituted
Cyclopropylidene Group in Place of a Sugar Moiety," J. Heterocyclic
Chem. 2000, 37, 951-953.
S. Siddiqui and R. S. Hosmane,
"Synthetic Analogues of Stilbene Containing an Imidazole Nucleus,"
Molecules 2000, 5, 856-863.
H. -M. Chen and R. S. Hosmane,
"Synthesis of 6-Amino-2-phenylimidazo [4,5-e][1,3]diazepine-4,8(1H,
5H)-dione," Molecules 2000, 5, M164.
V. Rajappan and R. S. Hosmane,
"A Model Study for a Novel Synthetic Approach to 2-Carboxyinosines," Tetrahedron
Lett. 2000, 41, 9713-9717.
Z. Sun and R. S. Hosmane,
"Photochromic Fulgides: Transformation of the Non-photochromic (Z)-Isomer
of a Fulgide into a Highly Photochromic (E)-Isomer via Structural
Modification Involving Enhanced Conjugation," J. Heterocyclic Chem.
2000, 37, 1439-1441.
S. P. Peri, V. S. Bhadti, R.
Liang, R. S. Hosmane, and V. W. Macdonald, "Affinity Reagents for
Cross-Linking Hemoglobin: Bis(phenoxycarbonylethyl) phosphinic Acid (BPCEP) and
Bis(3-nitrophenoxycarbonylethyl)phosphinic Acid (BNCEP)," Hemoglobin1999, 23, 1-20.
H. Chen, R. Sood, and R. S.
Hosmane, "An Efficient, Short Synthesis of
6-Imino-6-H-1-ß-D-ribofuranosyl-4,5,7,8-tetrahydroimidazo[4,5-e]diazepine-
4,8-dione: A Novel Ring-Expanded Purine Nucleoside Analogue Containing a
5:7-Fused, Planar, Aromatic, Heterocyclic Ring System," Nucleosides
& Nucleotides 1999, 18, 331-335.
M. Bretner, D. Beckett, R. Sood,
and R. S. Hosmane, "Substrate/Inhibition of Bacteriophage T7 RNA
Polymerase by the 5'-Triphosphate Derivative of a Ring-Expanded
("Fat") Nucleoside Possessing a Potent Anti-Hepatitis B Viral
Activity," Bioorg. Med. Chem. 1999, 7,
2931-2936.
V. Rajappan and R. S. Hosmane,
"Investigations into Biochemical Mode of Inhibition of Guanase by
Azepinomycin: Synthesis and Biochemical Screening of Several Analogues of
Azepinomycin," Nucleosides & Nucleotides 1999, 18,
835-836.
M. Bretner, D. Beckett, and R. S.
Hosmane, "Potent Anti-Hepatitis B Viral Activity and Inhibition of
Bacteriophage T7 RNA Polymerase by a ‘Fat" Nucleoside and Its
5'-Triphosphate Derivative: Synthetic, Biochemical, and Biological Studies of
4,8-Diamino-6-imino-6H-1-ß-D-ribofuranosyl- imidazo[4,5-e][1,3]
diazepine-5'-triphosphate," Nucleosides & Nucleotides1999,
18, 837-838.
J. Z. Dávalos, H. Flores, P.
Jiménez, R. Notario, M. V. Roux, E. Juaristi, R. S. Hosmane, and J. F. Liebman,
"Calorimetric, Calculational (G2(MP2) and G3) and Conceptual Study
of the Energetics of the Isomeric 1,3- and 1,4-Dithianes," J.
Org. Chem. 1999, 64, 9328-9336.
Y. S. Agasimundin, M. W. Mumper,
and R. S. Hosmane, "Inhibitors of Glycogen Phosphorylase B: Synthesis,
Biochemical Screening, and Molecular Modeling Studies of Novel Analogues of
Hydantocidin," Bioorg. Med. Chem. 1998, 6,
911-923.
V. P. Rajappan and R. S. Hosmane,
"Analogues of Azepinomcin as Inhibitors of Guanase," Nucleosides
& Nucleotides 1998, 17, 1141-1151.
V. P. Rajappan and R. S. Hosmane,
"Synthesis and Guanase Inhibition Studies of a Novel Ring-Expanded Purine
Analogue Containing a 5:7-Fused, planar, Aromatic Heterocyclic Ring
System," Bioorg. Med. Chem. Lett. 1998, 8,
3649-3652.
V. P. Rajappan and R. S. Hosmane,
"Pentafluorophenol: A Superior Reagent for Condensations in Heterocyclic
Chemistry," Synth. Commun. 1998, 28, 753-764.
R. S. Hosmane, S. P. Peri, V. S.
Bhadti, and V. W. Macdonald, "Bis[2-(4-carboxyphenoxy)carbonyl-
ethyl]phosphinic Acid (BCCEP): A Novel Affinity Reagent for the b-Cleft Modification of Human
Hemoglobin," Bioorg. Med. Chem.1998, 6, 767-783.
R. S. Hosmane and M. Hong,
"How Important Is the N-3 Sugar Moiety in the Tight-Binding Interaction of
Coformycin with Adenosine Deaminase?" Biochem. Biophys. Res. Commun.
1997, 236, 88-93.
F. N. Burnett and R. S. Hosmane,
"Imidazo[4,5-e][1,2,4]triazocine: A Novel 5:8-Fused Ring System Riddled
with Rearrangements," Heterocycles 1997,45, 857-861.
M. V. Roux, P. Jimęnez, M. Ŕ.
Martín-Luengo, J. Z. Dŕvalos, Z. Sun, R. S. Hosmane, J. F. Liebman, "The
Elusive Antiaromaticity of Maleimides and Maleic Anhydride: Enthalpies of
Formation of N-Methylmaleimide, N-Methylsuccinimide, N-Methylphthalimide and
N-Benzoyl-N-methyl- benzamide," J. Org. Chem. 1997, 62,
2732-2737.
M. Hong and R. S. Hosmane,
"Irreversible, Tight-Binding Inhibition of Adenosine Deaminase by
Coformycins: Inhibitor Structural Features that Contribute to the Mode of
Inhibition, " Nucleosides and Nucleotides1997, 16,
1053-1057.
S. P. Peri, V. S. Bhadti, R. S.
Hosmane, and V. W. Macdonald, "Bis[2-(4-carboxyphenoxy)carbonyl-
ethyl)phosphinic Acid (BCCEP): A New Reagent for Hemoglobin Modification,"
Artif. Cells Blood Subst. Immobil. Biotech. 1997, 25,
511-520.
My Laboratory
My Research Group
As of December 2008, I have had
more than 150 people who worked in my lab since I joined the faculty of UMBC in
1982, including high school seniors, undergraduates, graduate students,
post-doctoral research associates, visiting research scientists, and visiting
professors. While I have had the professional pleasure of collaborating
and/or training these various individuals in my specific research areas, I have
also benefitted and learnt a lot from them both professionally and
socially. Day-to-day interaction with my research group, in itself, has
been a great learning experience for me as my group over the past few years has
been a unique mix of racial and ethnic diversity, comprised of whites, blacks,
Indians, Chinese, Germans, French, Polish, Russians, Koreans, Syrians, and
Iranians. So far, 13 graduate students have earned Ph.D. degrees under my
supervision, 7 have earned M.S. degrees, and 7 more are currently working
toward Ph.D. All my former graduate and postdoctoral students have been well-placed
in academia, industry, or government. The following is a list of
some of the photographs of my research group over the years:
(0) Good Old Graduate Days of RSH Good
Old Graduate Days of RSH in the 70's (1) Research Group Picnic, 1986: Mike Rauser and Me. Mike
was an undergraduate student working in my lab, who went on to become a surgeon
in opthamology. (2) Research Group Picnic, 1987: (L to
R) Susan Babyak, Craig Bertha (M.S. 1989; Ph.D. 1992), Song Ho, Chong Son,
Warren Denis, Bert Ozgun, and myself. (3) Research Group Picnic, 1988: (L to
R) Seema Bhat, Mrinal Guha, Mala Hosmane, Pursottam Bhan, Kevin Bertha, Mrs.
Bertha, Aditya Bhat, Raji Hosmane, Ben Lim (M.S.; 1986, Ph.D. 1989), Craig
Bertha, Ruth Stevens, Ram Hosmane, Elaine Stevens, Mike Rauser, Bert
Ozgun. (4) Research Group Picnic, 1989: (L to
R) Fred Burnett (Ph.D. 1995), Ram Hosmane, Ram Mohan, Mala Hosmane, Anila Bhan,
Raji Hosmane, Mrs. Vaidya. (5) Research Group Picture, 1990:
The names are given on the back of their Group Teashirts. (6) Research Group Picture, 1991(in
front of the Chemistry building): (L to R) Mary Mumper (Ph.D. 1996), Anila Bhan
(Postdoc, 1985-95), Fred Burnett (Ph.D. 1995), Mi Kyung Hong (Ph.D. 1996),
Craig Bertha (Ph.D. 1992), Ram Hosmane, Vimisha Patel (Project SEED student),
Folami Baker (Project SEED student), Vishu Bhadti (Postdoc 1989-96). (7) Graduation , 1992 (with
Craig Bertha). (8) Research Group Picture, 1993: (L
to R) Peter (Zhiyuan) Sun (Visiting Professor, 1993-95), Srinivasan Natesan
(Visiting Scientist, 1993-94), Ben Lim (Postdoc, 1993-94 ), Sam Agasimundin
(Visiting Professor, 1993-94), Vishu Bhadti (postdoc, 1989-96), Fred Burnett
(Ph.D. 1995), Kumar Rajappan (Ph.D. 1998), Ram Hosmane (with toupee), Mi Kyung
Hong (Ph.D. 1996), Prasad Peri (Postdoc, 1993-97), Anila Bhan (Postdoc,
1985-95), Lijuan Wang (Ph.D. 1995), Mary Mumper (Ph.D. 1996). (9)
Research Group Picnic,
1994: (L to R) Vishu Bhadti (Postdoc, 1989-96), Anila Bhan (Postdoc
1985-95), Manik Bhan, Rhona Kalivretenos, Aris Kalivretenos, Mary Mumper (Ph.D.
1996), James Huang/Wang, David Huang, Lijuan Wang (Ph.D. 1995), Sam Agasimundin
(Visiting Professor, 1993-94), Fred Burnett (Ph.D. 1995), Mr. Hong, Mi Kyung
Hong (Ph.D. 1996), Ram Hosmane, Srinivasan Natesan (Visiting Scientist,
1993-94), Kumar Rajappan (Ph.D. 1998), Peter (Zhiyuan) Sun (Visiting Professor,
1993-95). (10) Dr. Hosmane addressing the convocation audience on the occasion
of receiving the Presidential
Research Professor award for the years 1998-2001 from the University on
Some
Additional Pictures of Family & Friends
My Favorite Entertainments
Indian Movies, Arts,
Dances, and Songs:
Laugh Till You Drop!
The Courses I Teach
(A) Undergraduate Courses:
CHEM 351:
Introd.
Organic Chemistry-Part I
CHEM 352:
Introd.
Organic Chemistry-Part II
CHEM 351L:
Org. Chem.
Laboratory-Part I
CHEM 352L:
Org. Chem.
Laboratory-Part II
CHEM 450:
Chem. of
Heterocyclic Compds
CHEM 450L:
Advanced
Organic Synthesis Lab
CHEM 453:
Organic Chem.
of Nucleic Acids
CHEM 455:
Introd. to
Biomedicinal Chemistry
(B) Graduate Courses:
CHEM 650:
Chem. of
Heterocyclic Compds
CHEM 653:
Organic Chem.
of Nucleic Acids
CHEM 654:
Advanced
Organic Synthesis
CHEM 655:
Introd. to
Biomedicinal Chemistry
Mail: Dr. Ramachandra S. Hosmane,
Department of Chemistry and
Biochemistry, UMBC, 1000 Hilltop Circle, Baltimore, MD 21250
Email: hosmane@umbc.eduOffice Phone:410-455-2520
Lab
Phones: 410-455-3844/3717/2562 Fax:410-455-1148
