WELCOME TO
THE HOME PAGE OF
Dr. Ramachandra S. Hosmane
Professor of Chemistry (Retired)

University of Maryland
(UMBC)

 

Personal data:

Born in Gokarn (N. Kanara), Karnataka, India
Family: Wife, Raji; Daughter: Mala
Citizenship: United States

Education:

B.Sc. 1966; M.Sc. 1968 - Karnataka University (India)
M.S. 1976; Ph.D. 1978 - University of South Florida (U.S.A.)
Postdtoral 1979 - 1982 - University of Illinois, Urbana-Champaign, IL (U.S.A)

Experience in Higher Education:

1994-2009:     Professor of Chemistry, University of Maryland (UMBC)
1986-1994:     Associate Professor of Chemistry, UMBC
1982-1986:     Assistant Professor of Chemistry, UMBC

Awards and Honors:

2009-2012:    Presidential Teaching Professor
2002:             Maryland Chemist of the Year Award
                      from American Chemical Society, Maryland Division
2000-2001:    Outstanding Educator of the Year Award
                      from Maryland Association for Higher Education (MAHE)
1998-2001:    Presidential Research Professor
1999:            Honorary Faculty Member, Golden Key National Honor Society
1996:            Outstanding Mentor, Project SEED (American Chemical Society)

Historical Record of Grant Support: (~$10 Million)

(41) National Institutes of Health (NIGMS, #1R01GM087738) Inhibition of HCV as an Opportunistic HIV Co-infection, 2008-12

(40) American Heart Association (#AHA 0755372U), Artificial Blood Based on Hemoglobin Dendrimers, 2007-09

(39) North American Biologicals, Inc. (Nabi) , Ring-Expanded Nucleosides & Nucleotides, 1999-09

(38) National Institutes of Health (NIAID, #R21AI071802), Mechanistic Studies of Anti-HIV Activity, 2006-09

(37) Greenbaum Cancer Center, UMB, Novel Nucleoside Analogs as Cancer Chemotherapeutics, 2006-07

(36) National Institutes of Health (NIAID, #R01AI55452), “Fat” Nucleosides & Nucleotides, 2002-07

(35) Grace Chemical Co., Synthesis of Novel Thiophene Analogues for Artificial Membranes, 2004-05

(34) National Institutes of Health (NHLBI, #R01HL48632), Novel Org. Reagents for Biomed. Appls, 1999-03

(33) National Institutes of Health (NHLBI, #R01HL48632-S1), Res. Suppl. Minority Undergrad. Asst., 2000-02

(32) Transbio Corp., Synthesis of a Novel Heterocycle for Sensitive Detn. of Proteins & Nucl. Acids, 2001-01

(31) Novadaq Corp., Canada, Synthesis of Indocyanine Green for Surgery in Opthamology, 2001-01

(30) National Institutes of Health ((NCI, #R01 CA71079),“Fat” & “Slim” Nucleosides & Nucleotides, 1996-00

(29) National Institutes of Health ((NCI, #R01 CA71079-S1), Res. Suppl. Minority Undergrad. Asst.,1997-00

(28) Maryland Industrial Partnership (MIPS #910.19), Nucleosides for Antiviral Activity, 1997-99

(27) National Science Foundation (Whalen, P. I.), High Field NMR Inter. Data Anal. & Modeling, 1996-98

(26) National Institutes of Health (NHLBI, #R01 HL33629), Novel Org. Reagents for Biomed. Appl., 1994-97

(25) Maryland Industrial Partnerships (MIPS #813.18), Stable Photochromic Compounds, 1994-96

(24) National Institutes of Health (NIGMS, #R01 GM49249), Novel Antiretroviral Nucleo(s/t)ides, 1992-96

(23) Boehringer-Mannheim Corp., Novel Heterocycles as Potential Therapeutic Agents, 1991-96

(22) National Institutes of Health (NIGMS, #R01 GM49249), Res. Suppl. Minority Grad. Asst., 1992-95

(21) Maryland Industrial Partnerships (MIPS, #1307.13), Novel Nucleosides for AIDS Therapy, 1992-95

(20) Rhone-Poulenc, Novel Heterocycles as Potential Agricultural Chemicals, 1991-95

(19) Maryland Industrial Partnerships (MIPS, #2001.27), Hemoglobin Blood Substitutes, 1991-94

(18) Martin-Marietta Laboratories, Synthesis of Photochromes for Holograms & Sensor Protection , 1993-94

(17) Autodesk, Inc., Design & Synthesis of Novel Organic Molecules for Biomedical Applications, 1992-93

(16) Burns Laboratories, Inc., Altered Nucleoside with Potential for AIDS Therapy, 1991-1993

(15) Burns Laboratories, Inc., Human Hemoglobin Cross-Linking Reagents, 1991-93

(14) National Institutes of Health (P.I. G. Rosen, UMB), Synthesis of Heterocyclic Spin Labels, 1990-92

(13) National Institutes of Health (NCI, #1R01 CA36154), “Fat” Nucleosides & Nucleotides, 1987-91

(12) Dow-Elanco Co., Novel Organics for Agricultural and Biomedical Applications, 1987-91

(11) Am. Cancer Soc.(MD Progr.), Is There a Correln bet. Conformn. & Activity of Nucleo(s/t)ides?, 1989-90

(10) Cytel Corporation, Biological Screening of Potential Immune Modulating Agents, 1989-90

(09) Monsanto Agricultural Co., Novel Heterocycles for Potential Agricultural Applications, 1989-94

(08) E. I. du Pont de Nemours & Co., Novel Het. Compds. as Potential Agricultural Chemicals, 1988-96

(07) American Heart Assoc., MD Affiliate, Inc., Synthetic Reagents to Cross-Link Hemoglobin, 1987-89

(06) Eli Lilly & Co., Novel Compounds for Potential Medicinal & Agricultural Applications, 1986-1993.

(05) National Institutes of Health (NHLBI, E. Bucci, P.I.), Hemoglobin-Based Oxygen Carriers, 1985-88

(04) Shell Development Company, Novel Compounds for Potential Agricultural Applications, 1985-86

(03) National Institutes of Health (NCI, #R01 CA36154), Synthetic Analogues of Coformycin, 1984-87

(02) Project SEED, Am. Chem. Soc., Summer Educational Experience for the Disadvantaged, 1983-00.

(01) Petroleum Research Fund, American Chemical Society, Total Synthesis of Coformycin, 1983-85

Professional Activities:

Editorial Activities: Managing Editor, Frontiers in Bioscience; current Topics in Medicinal Chemistry; Regional Editor, Molecules.

Panel Membership: Recent Grant Proposal Review Panels:


(1) Panel Member, NIH AIDS Discovery & Development Study Section [ADDT], 2002-2006
(2) Ad Hoc Member, NIH AIDS SBIR/STTR Study Section [AARR-E], 2002-2004
(3) Ad Hoc Member, NIH Drug Discovery, Development, and Delivery Study Section [SSS-L], 2004
(4) Ad Hoc Member, NIH Biodef. & Emerg. Infect. Diseases Study Sect. [ZAI 1 RCG-M (M2)], 2004
(5) Ad Hoc Member, NIH Hematology Bioengineering Study Section [ZRG1 HEME-D 50], 2005
(6) Ad Hoc Member, NIH Bioengineering Partnership Study Section [ZRG1-HEME-C-50R], 2006
(7) Ad Hoc Member, NIH RAID (Rapid Access to Intervention Development) Review Panel, 2006
(8) Ad Hoc Member, NIH Discov. &  Develop. Program Proj. (P01) Special Emphasis Panel, 2006
(9) Ad Hoc Member, NIH Program Project (P01), Blood Substitutes, Special Emphasis Panel, 2007
(10) Ad Hoc Member, NIH Co-op. Res. Partnership on Influenza (U01), Special Emph. Panel, 2007
(11) Ad Hoc Member, NIH AIDS Discovery & Develop. Special Emph. Panel (ZRG1-AARR-D), 2007
(12) Ad Hoc Member, FDA Site Visit Review Panel, Office of Biotechnology Products,
2/23/2007
(13) Ad Hoc Member, NIH AIDS Program Proj. & Center Grants Review Panel (ZRG1-AARR-A), 2007
(14) Ad Hoc Member, NIH AIDS Program Proj. (P01) Grants Rev. Panel [ZRG1 AARR-A (40)], 2007

(15) Ad Hoc Member, NIH Co-op. Res. Partnership in Biodefense, Special Emphasis Panel, 2007

(16) Ad Hoc Member, NIH Program Project (P01), Blood Substitutes, Sp.Emph.Panel, 2008

(17) Ad Hoc Member, NIH Minority Biomedical Res. Support (MBRS) Program in Chemistry, 2008

(18) Ad Hoc Member, NIH AIDS Progr. Proj. (P01) Rev. Panel [ZRG1 AARRA (40)], 2008

(19) Ad Hoc Member, NIH RAID (Rapid Access to Intervention Development) Review Panel, 2008

(20) Ad Hoc Member, NIH Diversity Fellowship Review Panel (ZRG1 SBIB-V (29)L)), 2009

(21) Ad Hoc Member, NIH/NHLBI Special Review Committee on Transfusion Medicine, 2009

(22) Ad Hoc Member, NIH/NIAID Challenge Grants Review Panel, 2009

Peer Reviewer: Grant Proposals: PRF, NIH, NSF, Am. Heart Assoc., Res. Corp., Guggenheim Foundation; Journals: JACS, JOC, Tet. Lett., J.Het.Chem., J. Med. Chem., Synthesis, Chem. Ber., Liebigs Ann. Chem., Nucleosides & Nucleotides, Nucl. Acids Res., J. Biomol.Struct. Dyn., Tetrahedron, Angewandte Chemie, Eur. J. Org. Chem., Hemoglobin, Bioorg. Med. Chem., Bioorg. Med. Chem. Lett.

Memberships: Sigma Xi; Affiliate IUPAC, Am. Chem. Soc., Chem. Soc.(London), Internat. Soc. Heterocycl. Chem., American Assoc. Adv. Science.

My Research Interests

My research interests areBiomedicinal Chemistry with applications inantiviral and anticancer therapy, as well asBiomedical Technology with applications inartificial blood. Our research, in general, involves computer-assistedmolecular modeling,organic synthesis,,biochemical & biophysical studies, and physiological & biological screening. The two specific current areas of research interests  include:

(A) "Fat" Nucleosides and Nucleotides as Potential Anticancer and Antiviral Agents:These novel ring-expanded ("fat") nucleoside/nucleotide analogues, designed and synthesized in this lab, have been found to be potent, broad-spectrum anticancer and antiviral agents with little, if any, toxicity to the host.  Our current focus is on prostate and breast cancers, as well as on West Nile, Hepatits B, and Hepatitis C viruses.  "Fat" nucleotides are potential modulators of tumor and/or viral DNA/RNA when incorporated, which may consequently result in nucleic acid chain termination ( Fig. 1), and hence inhibition of the viral or tumor replication.  In addition, because of their unique structural, spatial, and conformational characteristics, "fat" nucleosides/-tides are excellent probes for nucleic acid metabolism, structure, and function.
 

(B) Artificial Blood for Emergency Transfusions: One of our research areas focuses on developing substitutes for human blood for emergency transfusions.  In view of the current world events engulfed in terrorism and wars, the need for a blood substitute is becoming increasingly pressing. The scarcity of blood for emergency transfusions, especially when rare types are needed, the possible trans­mission of diseases associated with blood transfusion such as AIDS and hepatitis, the limitations on storage stability of intact blood, the necessity for blood typing before transfusion, and not to mention the ancillary religious reasons for non-acceptance of donated blood by certain ethnic individuals, give compelling impetus to pursue an alternative for whole blood.  To this end, we are involved in computer-aided design and chemical synthesis of novel polyfunctional organic reagents to cross‑link hemoglobin (see Fig. 2).   The modified cell-free hemoglobins are to be used in emergency transfusions with no necessity to type or cross-match the patient’s blood and with no fears of transmission of blood-borne diseases.  The covalently cross-linked hemoglobins are supposed to overcome the two major problems associated with cell-free hemoglobins, including their quick elimination by kidneys, and their too high oxygen affinity that prevents adequate oxygen transport from lungs to tissues.

 

My Awarded US & World Patents

R. S. Hosmane, V. Raman, and R. Kumar, "Fused Diimidazodiazepine Compounds and Methods of Use and Manufacture Thereof," US Patent# 8518901 B2, August 27, 2013.


R. S. Hosmane, V. Raman, and R. Kumar, "Fused Diimidazodiazepine Compounds as Antitumor Agents and Their Preparation, Pharmaceutical Compositions and Use in the Treatment of Cancers," World Patent# WO 2010039187 A2 20100408 , April 8, 2010.


R. S. Hosmane, R.K. Sood, "Ring-Expanded Nucleosides and Nucleotides," US Patent# 6677310 B1, January 13, 2004.


R. S. Hosmane, B. Burns, "Preparation of Ring-Expanded Nucleosides and Nucleotides as Virucides and Bactericides," US Patent# 5843912 A, December 1, 1998.


R. S. Hosmane, P. R. Rao, "Preparation of Acylsalicylates for Reducing the Mean Transit Time of Erythrocytes," US Patent# 5599959 A, February 4, 1997.


B. Burns, R.S. Hosmane "Preparation of ring-expanded bases, nucleosides and nucleotides as virucides, bactericides, fungicides, and parasiticides." World Patent# WO 9509175 A1 19950406 , April 6, 1995.


E. Bucci, C. Fronticelli-Bucci, R. S. Hosmane, "Preparation of Intramolecularly Cross-Linked Hemoglobin for Transfusion," US Patent# 4584130 A, April 22, 1986.


My Selected Research Publications (Out of ~160)

N. Zhang, P. Zhang, A. Baier, L. Cova, and R. S. Hosmane, "Dual Inhibition of HCV and HIV by Ring-Expanded Nucleosides Containing the 5:7-Fused Imidazo[4,5-e][1,3]diazepine Ring System. In Vitro Results and Implications," Bioorg. Med. Chem. Lett. 2014, 24, 1154-1157.


S. Tantravedi, S. Chakraborty, N. H. Shah, J. C. Fishbein, and R. S. Hosmane, "Analogs of Iso-Azepinomycin as Potential Transition-State Analog Inhibitors of Guanase: Synthesis, Biochemical Screening, and Structure-Activity Correlations of Various Selectively Substituted Imidazo[4,5-e][1,4]diazepines ," Bioorg. Med. Chem. 2013, 21, 4893-4903.


A. Kondaskar, S. Kondaskar, J. C. Fishbein, B. A. Carter-Cooper, R. G. Lapidus, M. Sadowska, M. J. Edelman, and R. S. Hosmane, "Structure-based Drug Design and Potent Anti-cancer Activity of Tricyclic 5:7:5-Fused Diimidazo[4,5-d:4',5'-f][1,3]diazepines," Bioorg. Med. Chem. 2013, 21, 618-631.


S. Chakraborty, N. H. Shah, J. C. Fishbein, and R. S. Hosmane, "Investigations into Specificity of Azepinomycin for Inhibition of Guanase: Discrimination between the Natural Heterocyclic Inhibitor and Its Synthetic Nucleoside Analogues," Bioorg. Med. Chem. Lett. 2012, 22, 7214-7218.


S. Chakraborty, N. H. Shah, J. C. Fishbein, and R. S. Hosmane, "A Novel Transition State Analogue Inhibitor of Guanase Based on Azepinomycin Ring Structure: Synthesis and Biochemical Assessment of Enzyme Inhibition," Bioorg. Med. Chem. Lett. 2011, 21, 756-759.


A. Kondaskar, S. Kondaskar, R. Kumar, N. Muvarak, R. G. Lapidus, M. Sadowska, M. J. Edelman, G. M. Bol, F. Vesuna, V. Raman, and R. S. Hosmane, "Novel, Broad Spectrum Anti-Cancer Agents Containing the Tricyclic 5:7:5-Fused Diimidazodiazepine Ring System," ACS Med. Chem. Lett. 2011, 2, 252-256.


H. Cai, T. A. Roach, M. Dabek, K. S. Somerville, S. Acharya, and R. S. Hosmane, "Bis[2-(3-carboxyphenoxy)carbonylethyl]phosphinic Acid (m-BCCEP): A Novel Affinity Cross-Linking Reagent for the b-Cleft Modification of Hemoglobin," Bioconj. Chem. 2010, 21, 1494-1507.


M. Xie, R. K. Ujjinamatada, M. Sadowska, R. G. Lapidus, M. J. Edelman, and R. S. Hosmane, "A Novel, Broad-Spectrum Anticancer Compound Containing the Imidazo[4,5-e][1,3]diazepine Ring System," Bioorg. Med. Chem. Lett. 2010, 20, 4386-4389.


K. Watashi, M. L. Yeung, M. F. Starost, R. S. Hosmane, and K. -T. Jeang, "Identification of Small Molecules that Suppress Micro RNA Function and Reverse Tumorigenesis," J. Biol. Chem. 2010, 285, 24707-24716.


R. S. Hosmane and J. F. Liebman, "Paradoxes and Paradigms: Why is Quinoline Less Basic than Pyridine or Isoquinoline? A Classical Organic Chemical Perspective,” Struct. Chem. 2009, 20, 693-697.


R. S. Hosmane, "Ring-Expanded ("Fat") Purines and Their Nucleoside/Nucleotide Analogues as Broad-Spectrum Therapeutics, ” Progr. Heterocycl. Chem. 2009, 21, 35-68.


R. Kumar, R. K. Ujjinamatada, and R. S. Hosmane ” The First Synthesis of a Novel 5:7:5-Fused Diimidazodiazepine Ring System and Some of Its Chemical Properties, ” Org. Lett. 2008, 10, 4681-4684.


V. S. R. K. Yedavalli, N. Zhang, P. Zhang, H. Cai, M. F. Starost, R. S. Hosmane, and K-T. Jeang, ” Ring-Expanded (REN) Nucleoside Analogues Inhibit RNA Helicase and Intracellular HIV-1 Replication, ” J. Med. Chem. 2008, 51, 5043-5051.

 

R. K. Ujjinamatada, P. Phatak, A. M. Burger, and R. S. Hosmane, “Inhibition of adenosine deaminase by analogues of adenosine and inosine incorporating a common heterocyclic base, 4(7)-amino-6(5)H-imidazo[4,5-d]pyridazin-7(4)one,” J. Med. Chem. 2008, 51, 694-698.

P. Zhang, N. Zhang, V. Buckwold, R. S. Hosmane, “Chemical and biological effects of substitution of the 2-position of ring-expanded (“fat”) nucleosides containing the imidazo[4,5-e][1,3] diazepine-4,8-dione ring system: The role of electronic and steric factors on glycosidic bond stability and anti-HCV activity,” Bioorg. Med. Chem., 2007, 15, 4933-4945.

R. K. Ujjinamatada, A. Baier, P. Borowski, and R. S. Hosmane, “An analogue of AICAR with dual inhibitory activity against WNV and HCV NTPase/helicase: Synthesis and in vitro screening of 4-carbamoyl-5- (4,6-diamino-2,5-dihydro-1,3,5-triazin-2-yl)imidazole-1-ß-D-ribofuranoside,” Bioorg. Med. Chem. Lett. 2007, 17, 2285-2288.

P. Zhang, N. Zhang, B. E. Korba, and R. S. Hosmane, “Structure-activity relationship studies on anti-HCV activity of ring-expanded (‘fat’) nucleobase analogues containing the imidazo[4,5-e][1,3]diazepine-4,8-dione ring system,” Bioorg. Med. Chem. Lett. 2007, 17, 2225-2228.

R. K. Ujjinamatada, A. Bhan, and R. S. Hosmane, "Design of Inhibitors Against Guanase:  Synthesis and Biochemical Evaluation of Analogues of Azepinomycin," Bioorg. Med. Chem. Lett. 2006, 16, 5551-5554. 


R. K. Ujjinamatada, R.L. Paulman, R. G. Ptak, and R. S. Hosmane, "Nucleosides with Self-Complementary Hydrogen-Bonding Motifs:  Synthesis and Base-Pairing Studies of Two Nucleosides Containing the Imidazo[4,5-d]pyridazine Ring System," Bioorg. Med. Chem. 2006, 14, 6359-6367.


P. Zhang, N. Zhang, B. E. Korba, and R. S. Hosmane, “Synthesis and In Vitro Anti-Hepatitis B and C Virus Activities of Ring-Expanded ("Fat") Nucleobase Analogues Containing the Imidazo[4,5-e][1,3]diazepine-4,8-dione Ring System,” Bioorg. Med. Chem. Lett. 2005, 15, 5397-5401.

 

R. K. Ujjinamatada and R. S. Hosmane, “Selective Functional Group Transformation Using Guanidne:  The Conversion of an Ester Group into an Amide in Vinylogous Ester-Aldehydes,” Tetrahedron Lett.  2005, 46, 6005-6009.

 

R. K. Ujjinamatada, Y. S. Agasimundin, P. Zhang, V. Koch, H. Schmitz, P. Borowski, K. Kalicharran, A. Fattom, and R. S. Hosmane, “A Novel Imidazole Nucleoside Containing a Diaminodihydro-s-Triazine as a Substituent and an Inhibitory Activity against the West Nile Virus NTPase/Helicase,” Nucleosides Nucleotides Nucleic Acids 2005, 24, 1775-1788. 

Ujjinamatada, R. K., Agasimundin, Y. S., Borowski, P., and Hosmane, R. S., “ Reactions of Guanidine with Vinylogous Ester-Aldehydes:  Synthesis and Anti-West Nile Virus Activity of a Novel Imidazole Nucleoside Containing a Diaminodihydro-s-triazine as a Substituent,” Antiviral Res. 2005, 65, A68-A69. 

T. A. Roach, V. W. Macdonald, and R. S. Hosmane, “A Novel Site-Directed Affinity Reagent for Cross-Linking Human Hemoglobin: Bis[2-(4-phosphonooxy phenoxy)carbonylethyl]phosphinic Acid (BPPCEP)” J. Med. Chem., 2004, 47, 5847-5859.

S. Gunther, M. Asper, C. Roser, L.K.S. Luna, C. Drosten, B. Becker-Ziaza, P. Borowski, and R. S. Hosmane, "Applications of Real-Time PCR for Testing Antivial Compounds Against Lassa Virus, SARS CoronaVirus, and Ebola Virus In Vitro," Antiviral Res. 2004, 63, 209-215.

A. Reayi and R. S. Hosmane, “Inhibition of Adenosine Deaminase by Novel 5:7-Fused Heterocycles Containing the Imidazo[4,5-e][1,2,4]triazepine Ring System: A Structure-Activity Relationship Study,” J. Med. Chem. 2004, 47, 1044-1050.

A. Reayi and R. S. Hosmane, "Inhibitors of Adenosine Deaminase:  Continued Studies of Structure-Activity Relationships in Analogues of Coformycin," Nucleosides Nucleotides Nucleic Acids 2004, 23, 263-270.

R. S. Hosmane and J. F. Liebman, “Resonance Stabilization in Diazophenoxides,” Struct. Chem. 2004, 15, 253-255.

N. Zhang, H.-M. Chen, V. Koch, H. Schmitz, C.-L. Liao, M. Bretner, V. S. Bhadti, A. I. Fattom, R. B. Naso, R. S. Hosmane, and P. Borowski, "Ring-Expanded Nucleoside and Nucleotide (REN) Analogues Exhibit Potent In Vitro Activity Against Flaviviridae NTPases/Helicases, including Those of the West Nile Virus (WNV), Hepatitis C Virus (HCV), and Japanese Encephalitis Virus (JEV)," J. Med. Chem. 2003, 46, 4149-4164.

N. Zhang, H.-M. Chen, V. Koch, H. Schmitz, C.-L. Liao, A. I. Fattom, R. B. Naso, K. Kalicharran, P. Borowski, and R. S. Hosmane, "Potent inhibition of NTPase/helicase of the West Nile Virus by Ring-Expanded Nucleoside (REN) Analogues," J. Med. Chem. 2003, 46, 4776 - 4789.

R. S. Hosmane, “Antiviral Agents,” in Kirk-Othmer Encyclopedia of Chemical Technology, John Wiley & Sons, New York, 2003 (invited article) <http://www.mrw.interscience.wiley.com/kirk/articles/antireva.a01/bibliography-fs.html>

Borowski, P., zur Wiesch, J. C. R. S., Schmitz, H., and Hosmane, R. S., “Inhibition of HCV NTPase/Helicase by Ring-Expanded Nucleosides (RENs),” Hepatology 2003, 38,624A-625A.

F. N. Burnett and R. S. Hosmane, "Synthesis of a Novel Ring-Expanded Purine Analogue Containing a 5:8-Fused Imidazo[4,5-e][1,2,4]triazocine Ring System Amidst Opportunistic Rearrangements and Ring Transformations," Tetrahedron 2002, 58, 9567-9578.

N. Zhang, H. -M. Chen, R. Sood, K. Kalicharran, A. I. Fattom, R. B. Naso, D. L. Barnard, R. W. Sidwell, and R. S. Hosmane, "In Vitro Inhibition of Measles Virus Replication by Novel Ring-Expanded (“Fat”) Nucleoside Analogues Containing the Imidazo[4,5-e][1,3]diazepine Ring System, Bioorg. Med. Chem. Lett.  2002, 12, 3391-3394.

R. Hosmane, "Ring-Expanded ("Fat") Nucleosides as Broad-Spectrum Anticancer and Antiviral Agents," in "Current Topics in Medicinal Chemistry: Recent Developments in Antiviral Nucleosides, Nucleotides, and Oligonucleotides," Hosmane, R. S., Ed., Bentham Science Publishers, 2002, Vol. 2, pp. 1093-1109.

R. Hosmane, "Coformycin and Analogues as Inhibitors of Adenosine Deaminase," in "Modified Nucleosides, Synthesis, and Applications," Loakes, D, Ed., Transworld Research Network, Trivendrum, 2002; pp.133-151.

P. Borowski, M. Lang, A. Haag, H. Schmitz, J. Choe, H. -M. Chen, and R. S. Hosmane, "Characterization of Imidazo[4,5-d]pyridazine Nucleosides as Modulators of Unwinding Reaction Mediated by West Nile Virus NTPase/Helicase: Evidence for Activity on the Level of Substrate and/or Enzyme," Antimicrob. Agents Chemotherap. 2002, 46, 1231-1239.

R. K. Sood, V. S. Bhadti, A. I. Fattom, R. B. Naso, H. Chen, B. E. Korba, E. Kern, and R. S. Hosmane, "Novel Ring-Expanded Nucleoside Analogs Exhibit Potent and Selective Inhibition of Hepatitis B Virus Replication in Cultured Human Hepatoblastoma Cells," Antiviral Res., 2002,53, 159-164.

P. Borowski, A. Niebuhr, H. Schmitz, R. S. Hosmane, M. Bretner, M. A. Siwecka, and T. Kulikowski, "NTPase/Helicase of Flaviviridae: Inhibitors and Inhibition of the Enzyme," Acta Biochem. Polon. 2002, 49, 597-614.

M. V. Roux, M. Temprado, J. Z. Dávalos, P. Jiménez, R. S. Hosmane, and J. F. Liebman, "Enthalpy of Formation of Methyl Benzoate: Calorimetry and Consequences," Phys. Chem. Chem. Phys. 2002, 4, 3611-3613.

R. S. Hosmane and J. F. Liebman, "Diazomethane and Ethyl Diazoacetate: The Role of Substituent Effects on Stability," Struct. Chem. 2002, 5-6, 501-503.

H. -M. Chen and R. S. Hosmane, "Synthesis of a Novel Ring-Expanded ("Fat") Nucleotide Analogue of Phosphonomethoxyethylguanine (PMEG) Containing the Imidazo[4,5-e][1,3]diazepine Ring System," J. Heterocycl. Chem. 2001, 38, 1313-1315.

L. Wang and R. S. Hosmane, "A Unique Ring-Expanded Acyclic Nucleoside Analogue That Inhibits Both Adenosine Deaminase (ADA) and Guanine Deaminase (GDA; Guanase):  Synthesis and Enzyme Inhibition Studies of 4,6-Diamino-8-H-1-hydroxyethoxymethyl-8-iminoimidazo[4,5-e][1,3]diazepine, " Bioorg. Med. Chem. Lett.  2001, 11, 2893-2896.

H. -M. Chen and R. S. Hosmane, "Synthesis of 1-(2'-O-Methyl-ß-D-ribo- furanosyl)-1H-imidazo[4,5-d]- pyridazine-4,7(5H,6H)-dione: An Attractive Building Block for Antisense and Triple-helical Applications," Molecules 2001, 6, 203-207.

J. Gill, M. Bretner, R. Newman, N. Kyprianou, and R. S. Hosmane, "Synthesis, Anticancer Activity, and In Vitro Mechanistic Investigations of Several "Fat" Nucleosides Containing the Imidazo[4,5-e][1,3] diazepine Ring System," Nucleosides & Nucleotides 2001, 20, 1043-1045.

H. -M. Chen and R. S. Hosmane, "Acyclic Nucleoside/Nucleotide Analogues Bearing an Imidazole Ring Skeleton," Nucleosides & Nucleotides 2001, 20, 1599-1614.

Z. Sun and R. S. Hosmane, "An Improved Synthesis of 9-Benzyladenine: A Model for Adenosine and Its Analogues," Synth. Commun. 2001, 32, 549-554.

R. K. Sood, V. S. Bhadti, H. -M. Chen, and R. S. Hosmane, "6-Amino-1-(2'-deoxy-b-D-ribofuranosyl)-4,5-dihydro-8H-imidazo[4,5-e][1,3]diazepine-4,8-dione," Molecules2001, 6, M264.

H. -M. Chen and R. S. Hosmane, "Synthesis of 1-(2'-Deoxy-ß-D-ribo- furanosyl)-1H-imidazo [4,5-d]- pyridazine-4,7(5H,6H)-dione: a Potentially Useful Building Block for Antisense Applications," Molecules 2000, 5, 1187-1193.

H. -M. Chen and R. S. Hosmane, "Synthesis of a Novel Ring-Expanded Nucleoside Analogue Containing the Imidazo[4,5-e][1,3]diazepine Ring System With a Guanidinocarbamoyl- Substituted Cyclopropylidene Group in Place of a Sugar Moiety," J. Heterocyclic Chem. 2000, 37, 951-953.

S. Siddiqui and R. S. Hosmane, "Synthetic Analogues of Stilbene Containing an Imidazole Nucleus," Molecules 2000, 5, 856-863.

H. -M. Chen and R. S. Hosmane, "Synthesis of 6-Amino-2-phenylimidazo [4,5-e][1,3]diazepine-4,8(1H, 5H)-dione," Molecules 2000, 5, M164.

V. Rajappan and R. S. Hosmane, "A Model Study for a Novel Synthetic Approach to 2-Carboxyinosines," Tetrahedron Lett. 2000, 41, 9713-9717.

Z. Sun and R. S. Hosmane, "Photochromic Fulgides: Transformation of the Non-photochromic (Z)-Isomer of a Fulgide  into a Highly Photochromic (E)-Isomer via Structural Modification Involving Enhanced Conjugation," J. Heterocyclic Chem. 2000, 37, 1439-1441.

S. P. Peri, V. S. Bhadti, R. Liang, R. S. Hosmane, and V. W. Macdonald, "Affinity Reagents for Cross-Linking Hemoglobin: Bis(phenoxycarbonylethyl) phosphinic Acid (BPCEP) and Bis(3-nitrophenoxycarbonylethyl)phosphinic Acid (BNCEP)," Hemoglobin1999, 23, 1-20.

H. Chen, R. Sood, and R. S. Hosmane, "An Efficient, Short Synthesis of 6-Imino-6-H-1-ß-D-ribofuranosyl-4,5,7,8-tetrahydroimidazo[4,5-e]diazepine- 4,8-dione: A Novel Ring-Expanded Purine Nucleoside Analogue Containing a 5:7-Fused, Planar, Aromatic, Heterocyclic Ring System," Nucleosides & Nucleotides 1999, 18, 331-335.

M. Bretner, D. Beckett, R. Sood, and R. S. Hosmane, "Substrate/Inhibition of Bacteriophage T7 RNA Polymerase by the 5'-Triphosphate Derivative of a Ring-Expanded ("Fat") Nucleoside Possessing a Potent Anti-Hepatitis B Viral Activity," Bioorg. Med. Chem. 1999, 7,  2931-2936.

V. Rajappan and R. S. Hosmane, "Investigations into Biochemical Mode of Inhibition of Guanase by Azepinomycin: Synthesis and Biochemical Screening of Several Analogues of Azepinomycin," Nucleosides & Nucleotides 1999, 18, 835-836.

M. Bretner, D. Beckett, and R. S. Hosmane, "Potent Anti-Hepatitis B Viral Activity and Inhibition of Bacteriophage T7 RNA Polymerase by a ‘Fat" Nucleoside and Its 5'-Triphosphate Derivative: Synthetic, Biochemical, and Biological Studies of 4,8-Diamino-6-imino-6H-1-ß-D-ribofuranosyl- imidazo[4,5-e][1,3] diazepine-5'-triphosphate," Nucleosides & Nucleotides1999, 18, 837-838.

J. Z. Dávalos, H. Flores, P. Jiménez, R. Notario, M. V. Roux, E. Juaristi, R. S. Hosmane, and J. F. Liebman, "Calorimetric, Calculational (G2(MP2) and G3) and Conceptual Study of the Energetics of the Isomeric 1,3- and 1,4-Dithianes," J. Org. Chem. 1999, 64, 9328-9336.

Y. S. Agasimundin, M. W. Mumper, and R. S. Hosmane, "Inhibitors of Glycogen Phosphorylase B: Synthesis, Biochemical Screening, and Molecular Modeling Studies of Novel Analogues of Hydantocidin," Bioorg.  Med. Chem. 1998, 6, 911-923.

V. P. Rajappan and R. S. Hosmane, "Analogues of Azepinomcin as Inhibitors of Guanase," Nucleosides & Nucleotides 1998, 17, 1141-1151.

V. P. Rajappan and R. S. Hosmane, "Synthesis and Guanase Inhibition Studies of a Novel Ring-Expanded Purine Analogue Containing a 5:7-Fused, planar, Aromatic Heterocyclic Ring System," Bioorg. Med. Chem. Lett. 1998 8, 3649-3652.

V. P. Rajappan and R. S. Hosmane, "Pentafluorophenol: A Superior Reagent for Condensations in Heterocyclic Chemistry," Synth. Commun. 1998, 28, 753-764.

R. S. Hosmane, S. P. Peri, V. S. Bhadti, and V. W. Macdonald, "Bis[2-(4-carboxyphenoxy)carbonyl- ethyl]phosphinic Acid (BCCEP): A Novel Affinity Reagent for the b-Cleft Modification of Human Hemoglobin," Bioorg. Med. Chem.1998, 6, 767-783.

R. S. Hosmane and M. Hong, "How Important Is the N-3 Sugar Moiety in the Tight-Binding Interaction of Coformycin with Adenosine Deaminase?" Biochem. Biophys. Res. Commun. 1997, 236, 88-93.

F. N. Burnett and R. S. Hosmane, "Imidazo[4,5-e][1,2,4]triazocine: A Novel 5:8-Fused Ring System Riddled with Rearrangements," Heterocycles 1997,45, 857-861.

M. V. Roux, P. Jimęnez, M. Ŕ. Martín-Luengo, J. Z. Dŕvalos, Z. Sun, R. S. Hosmane, J. F. Liebman, "The Elusive Antiaromaticity of Maleimides and Maleic Anhydride: Enthalpies of Formation of N-Methylmaleimide, N-Methylsuccinimide, N-Methylphthalimide and N-Benzoyl-N-methyl- benzamide," J. Org. Chem. 1997, 62, 2732-2737.

M. Hong and R. S. Hosmane, "Irreversible, Tight-Binding Inhibition of Adenosine Deaminase by Coformycins: Inhibitor Structural Features that Contribute to the Mode of Inhibition, " Nucleosides and Nucleotides1997, 16, 1053-1057.

S. P. Peri, V. S. Bhadti, R. S. Hosmane, and V. W. Macdonald, "Bis[2-(4-carboxyphenoxy)carbonyl- ethyl)phosphinic Acid (BCCEP): A New Reagent for Hemoglobin Modification," Artif. Cells Blood Subst. Immobil. Biotech. 1997, 25, 511-520.
 
 
My Laboratory

My Research Group

As of December 2008, I have had more than 150 people who worked in my lab since I joined the faculty of UMBC in 1982, including high school seniors, undergraduates, graduate students, post-doctoral research associates, visiting research scientists, and visiting professors.  While I have had the professional pleasure of collaborating and/or training these various individuals in my specific research areas, I have also benefitted and learnt a lot from them both professionally and socially.  Day-to-day interaction with my research group, in itself, has been a great learning experience for me as my group over the past few years has been a unique mix of racial and ethnic diversity, comprised of whites, blacks, Indians, Chinese, Germans, French, Polish, Russians, Koreans, Syrians, and Iranians.  All my former graduate and postdoctoral students have been well-placed in academia, industry, or government.   The following is a list of some of the photographs of my research group over the years:

(0) Good Old Graduate Days of RSH Good Old Graduate Days of RSH in the 70's (1) Research Group Picnic, 1986: Mike Rauser and Me. Mike was an undergraduate student working in my lab, who went on to become a surgeon in opthamology.  (2) Research Group Picnic, 1987: (L to R) Susan Babyak, Craig Bertha (M.S. 1989; Ph.D. 1992), Song Ho, Chong Son, Warren Denis, Bert Ozgun, and myself.  (3) Research Group Picnic, 1988: (L to R) Seema Bhat, Mrinal Guha, Mala Hosmane, Pursottam Bhan, Kevin Bertha, Mrs. Bertha, Aditya Bhat, Raji Hosmane, Ben Lim (M.S.; 1986, Ph.D. 1989), Craig Bertha, Ruth Stevens, Ram Hosmane, Elaine Stevens, Mike Rauser, Bert Ozgun.  (4) Research Group Picnic, 1989: (L to R) Fred Burnett (Ph.D. 1995), Ram Hosmane, Ram Mohan, Mala Hosmane, Anila Bhan, Raji Hosmane, Mrs. Vaidya.  (5) Research Group Picture, 1990:  The names are given on the back of their Group Teashirts.  (6) Research Group Picture, 1991(in front of the Chemistry building): (L to R) Mary Mumper (Ph.D. 1996), Anila Bhan (Postdoc, 1985-95), Fred Burnett (Ph.D. 1995), Mi Kyung Hong (Ph.D. 1996), Craig Bertha (Ph.D. 1992), Ram Hosmane, Vimisha Patel (Project SEED student), Folami Baker (Project SEED student), Vishu Bhadti (Postdoc 1989-96).  (7) Graduation , 1992 (with Craig Bertha).  (8) Research Group Picture, 1993: (L to R) Peter (Zhiyuan) Sun (Visiting Professor, 1993-95), Srinivasan Natesan (Visiting Scientist, 1993-94), Ben Lim (Postdoc, 1993-94 ), Sam Agasimundin (Visiting Professor, 1993-94), Vishu Bhadti (postdoc, 1989-96), Fred Burnett (Ph.D. 1995), Kumar Rajappan (Ph.D. 1998), Ram Hosmane (with toupee), Mi Kyung Hong (Ph.D. 1996), Prasad Peri (Postdoc, 1993-97), Anila Bhan (Postdoc, 1985-95), Lijuan Wang (Ph.D. 1995), Mary Mumper (Ph.D. 1996).  (9) Research Group Picnic, 1994: (L to R) Vishu Bhadti (Postdoc, 1989-96), Anila Bhan (Postdoc 1985-95), Manik Bhan, Rhona Kalivretenos, Aris Kalivretenos, Mary Mumper (Ph.D. 1996), James Huang/Wang, David Huang, Lijuan Wang (Ph.D. 1995), Sam Agasimundin (Visiting Professor, 1993-94), Fred Burnett (Ph.D. 1995), Mr. Hong, Mi Kyung Hong (Ph.D. 1996), Ram Hosmane, Srinivasan Natesan (Visiting Scientist, 1993-94), Kumar Rajappan (Ph.D. 1998), Peter (Zhiyuan) Sun (Visiting Professor, 1993-95). (10) Dr. Hosmane addressing the convocation audience on the occasion of receiving the Presidential Research Professor award for the years 1998-2001 from the University on October 2, 1998. (11) Group Picnic, 1999 (Large Central Panel with Caption), (L to R) First Row (F to B): Julie Gill (B.S. 1999), Saika Siddiqui (M.S. 1999), Njeri Ngaine, Karla Somerville-Armstrong, Mike Armstrong; Second Row (F to B): Maria Bretner (Research Associate, 1997-99), Bruce Gustafson, Tim Roach; Third Row(F to B): Ning Zhang, Ayub Reayi, Mrs. Shairose Reayi; Fourth Row(F to B): Lino Korah, Naznin Vahora, Huanming Chen (Research Associate, 1997-), Sunny Chen; missing from the photograph (see the panel immediately above for the picture):  Jessica Metzler (sitting with Bruce Gustafson and Mike Armstrong).  (12) Group Picnic 2001 (June 29): (L to R) Peng Zhang, Mrs. Akkamahadevi Agasimundin, Dr. Yankanagouda (Sam) Agasimundin, Henok Aynalem, Stacey Simmons, Ram Hosmane, Bruce Gustafson, Ning Zhang, missing from the picture (Ayub Reayi).  (13)Additional Pictures from Group Picnic 2001 (Part I)  (14) Graduation Pictures of Karla Somerville-Armstrong on December 20, 2001 (15) Picture of Meera Shah (M. S., 2002) (16) Group Picnic Pictures 8/1/2002 (Part I)  (17) Group Picnic Pictures 8/1/2002 (Part II) (18) Group Picnic Pictures 8/1/2002 (Part III) (19) The U.S. Visit of My Friend and Collaborator Dr. Peter Borowski and His Wife Edith from Hamburg, Germany During September 24-26, 2002.  (20) Pictures from the Maryland Chemist of the Year Award Ceremony (UMBC News Release), December 11, 2002.  (21) Rose (M.S. 1998) with Her Husband Lee and Daughter Emily (2003)   (22) Research Group Pictures of 2003 (Lunch at Old Country Buffet (Summer '03)  (23) Graduation Party at Hosmane Residence for Ayub Reayi (Ph.D., '03) and Tim Roach (Ph.D., '03) on December 16, 2003  (24) Graduation Pictures of Ayub Reayi (Ph.D., '03) on December 18, '03.  (25) Research Group Barbeque Dinner at Hosmane Residence on July 5, 2004.  (26) Annual Research Group Picnic at Cunnigham Falls State Park on July 23, 2004.  (27) More Pictures of Group Picnic on July 23, 04  (28) Birthday Celebration at Bombay Grill, Towson, MD on December 5, 2004:  (a) Part-I,  (b) Part-II   (29) Ning Zhang Graduation Party at Hosmane Residence on November 19, 2005 (30) Research Group Picture_05 (31) Peng (Penny) Zhang Graduation Party at Hosmane Residence on March 10, 2007 (32) Peng Zhang Convocation Pictures 2007 (33) Group Picnic 2007 at Gunpowder Falls State Park   (34) Thanksgiving Party of RSH Group on Saturday November 17, 2007   (35) Surprise Birthday Party at Hosmane Residence on December 9, 2007   (36) Group Lunch at Indian Delight Restaurant on December 27, 2007 (37) Group Photo with Dr. Rama Rao, Director, NIPER, India on June 19, 2008 (38) (a) Group Picnic 2008_Part-I at Greenbriar State Park (b) Group Picnic Part-II (c) Group Picnic Part-III (39) Surprise Birthday Party for Dr. Hosmane & Min Xie at the Department on December 12, 2008   (40) Farewell Party for Dr. Ravi Ujjinamatada and his family, including his wife Ashwini and daughter Prisha at the Department on January 1, 2009   (41) Presidential Teaching Professor Award to Dr. Hosmane, April 2009, for the years 2009-2012 (42) Keynote Speech at the UMBC Fall Convocation on August 31, 2009(43) Group Picnic 2009, Susquehanna State Park, Havre de Grace, Maryland (44) Surprise Birthday Party for Dr. Hosmane & Sarah Wang (Min Xie) at the Department on December 14, 2009   (45) Retirement Party Pictures of Dr. Hosmane at Hosmane Residence on Jan 6, 2010 (46) Group Picnic Pictures, 2010, at Greenbriar State Park, August 7, 2010   (47) 66th Birthday Party Pictures of Dr. Hosmane at Hosmane Residence on December 7, 2010   (48) Potluck Lunch at Hosmane Residence on February 5, 2011   (49) Family Pictures of Dr. Raj Kumar (Postdoc 2007-08), Mrs. Shweta Raj Kumar and Master Tanvish Raj Kumar   (50) Potluck Lunch at Hosmane Residence on June 18, 2011  (51) Birthday Celebrations of Saritha and Tanvish Raj Kumar August, 2011   (52) The Last Supper with the Hosmanes' at their Maryland residence on October 12, 2011   (53) Doctoral Graduation Party Pictures Taken on May 18 and May 19, 2012   (54) Wedding Pictures of Drs. Margaret and Bryan Curtin, June 1, 2012  

Some Additional Pictures of Family & Friends

My Favorite Entertainments

Indian Movies, Arts, Dances, and Songs:

Laugh Till You Drop!

Click on the Image below

The Courses I Taught

(A) Undergraduate Courses:
  CHEM 351: Introd. Organic Chemistry-Part I
 CHEM 352: Introd. Organic Chemistry-Part II
  CHEM 351L: Org. Chem. Laboratory-Part I
  CHEM 352L: Org. Chem. Laboratory-Part II
  CHEM 450: Chem. of Heterocyclic Compds
 CHEM 450L: Advanced Organic Synthesis Lab
  CHEM 453: Organic Chem. of Nucleic Acids
 CHEM 455: Introd. to Biomedicinal Chemistry
 CHEM 457: Total Synthesis of Nat. Products
 
 

(B) Graduate Courses:
 CHEM 650: Chem. of Heterocyclic Compds
 CHEM 653: Organic Chem. of Nucleic Acids
 CHEM 654: Advanced Organic Synthesis
CHEM 655: Introd. to Biomedicinal Chemistry
 CHEM 657: Total Synthesis of Nat. Products
 
 





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hosmane@umbc.edu















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August 12, 1998