Outline

1. Introduction

1.1. Environmental design
1.2. Fermentation design
1.3. Scope of the project

2. Basic modes of operation

2.1. Batch fermentation
2.2. Continuous culture
2.3. Fed-Batch reactors

3. Fed-Batch fermentations

3.1. Fixed volume fed-batch
3.2. Variable volume fed-batch
3.3. Advantages and disadvantages of fed-batch culture
3.4. Equipment
3.4.1. Vessels
3.4.2. Pumps
3.5. Control techniques for fed-batch fermentations
3.6. Modelling of fed-batch reactors
3.6.1. Fixed volume fed-batch
3.6.2. Variable volume fed-batch
3.6.3. Models of possible situations that may occur in fed-batch fermentation
3.7. Parameters used to control fed-batch fermentations
3.7.1. Calorimetry
3.7.2. Specific growth rate
3.7.3. Substrate (carbon or nitrogen source)
3.7.4. By-product concentration
3.7.5. Inductive, enhancer or enrichment components
3.7.6. Respiratory quotient
3.7.7. General feeding mode
3.7.8. Proton production rate
3.7.9. Fluorescence
3.8. Parameters to start and finish the feed, and stop the fed-batch fermentation
3.9. Preliminary knowledge required to implement fed-batch
3.10. Algorithms for operating a fed-batch reactor at optimum specific growth rate (model independent and applicable to adapting systems)
3.11. Some examples of fed-batch use in industry

4. Conclusion


5. References

6. Related Web links